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Targeted Mesoporous Silica Nanoparticles Drug Delivery System Loading Fluorescent Selenocompound For Cancer Theranosis
YANG Liye,ZHENG Wenjie,CHEN Tianfeng * #
Department of Chemistry, Jinan University, Guangzhou 510632, China
*Correspondence author
#Submitted by
Subject:
Funding: 863 National High Technology Research and Development Program of China （No.SS2014AA020538）, the Program for New Century Excellent Talents in University and Research Fund for the Doctoral Program of Higher Education of China（No.20114401110004）, the National Natural Science Foundation of China（No.21171114, 21271002 and 21371076）, Guangdong Natural Science Funds for Distinguished Young Scholar（No.S2013050014667）
Opened online: 9 June 2014
Accepted by: none
Citation: YANG Liye,ZHENG Wenjie,CHEN Tianfeng.Targeted Mesoporous Silica Nanoparticles Drug Delivery System Loading Fluorescent Selenocompound For Cancer Theranosis[OL]. [ 9 June 2014] http://en.paper.edu.cn/en_releasepaper/content/4599165
 
 
Organic selenium compounds as a potential anticancer agent have drawn attention by a great deal of biological and chemical scientists in recent decades. Howbeit, its application in higher cellular uptake and better inter-cellular selectivity is still challenging. Herein, we depict the synthesis of RGD integrin-conjugated PEI coated MSNs loading an organic selenium compound to achieve a cancer-targeted drug delivery system (CtDDS) and its great use in enhanced cellular uptake and high anti-proliferation efficacy. Mesoporous silica nanoparticles (MSNs), an electronegative carrier, have a high loading capacity for its porous structure. PEI, a cationic polymer could enhance cellular uptake as a result of positive charge and improve the stability of MSNs. Also, RGD integrin could recognize and lead the nanoparticles into different cells by conjugated with PEI. Intracellular trafficking of BSeC@MSNs behaves in lysosome after pH-controlled release. Anti-proliferation activity of BSeC was dramatically increased by the CtDDS. BSeC@MSNs could select and induce the apoptosis of RGD-receptor over-expressed cell lines. Both intrinsic and extrinsic ways could be activated by P53 mediated apoptosis paths and MAPKs kinase family was also activated. These results indicate that the BSeC@MSNs could be used as a promising cancer-targeted drug delivery system and a better application of amelioration of organic selenium compound in diagnostic aspects.
Keywords:Inorganic chemistry, Mesoporous silica nanoparticles, selenocompounds, RGD peptide, theranostics.
 
 
 

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