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| Metastasis is the major cause of prostate cancer deaths.Cortactin is a protein that has been shown to be critical for the cancer cell migration and invasion and play an important role in tumor metastasis. However, the clinical significance of cortactin in prostate cancer and the role of cortactin in the progression and metastasis of prostate cancer are still not clear. In this study, we examined the cortactin expression in benign prostate and different stages of prostate cancer tissues including 26 BPH, 82 untreated primary cancer, 58 NHT cancer, 20 CRPC, and 13 metastatic prostate cancer tissues, and analyzed its relationship with clinicopathological factors. The result showed that cortactin expression increased gradually in different stages of cancer progression and was associated with prostate cancer metastasis. Further functional analysis showed that knockdown of cortactin protein by siRNA led to a marked reduction in PC-3 cell invasive ability and extracellular matrix degradation. Our findings suggested that expression of cortactin is correlated with the progression of clinical prostate cancer to more aggressive stages and provided support for the role of cortactin in prostate cancer cell invasion. Cortactin may serve as a promising biomarker and therapeutic target for metastatic prostate cancer. |
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| Keywords:cortactin, prostate cancer, invasiveness |
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