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Concise Total Synthesis of (±)- Pisiferin
Yulong Li,Liqi Li,Yueming Guo,Zhixiang Xie * #
College of Chemistry and Chemical Engineering & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou City, 730000
*Correspondence author
#Submitted by
Subject:
Funding: SFC Grant (No.No. 21272104), RFDP Foundation (No.No. 20110211110009)
Opened online: 9 April 2015
Accepted by: none
Citation: Yulong Li,Liqi Li,Yueming Guo.Concise Total Synthesis of (±)- Pisiferin[OL]. [ 9 April 2015] http://en.paper.edu.cn/en_releasepaper/content/4636172
 
 
A concise total synthesis of (±)-pisiferin has been accomplished from α-cycloiral via Suzuki coupling and F-C alkylation as key reaction in five steps with an overall yield of 16%. The feature of this concise strategy is using acetyl group to protect the phenol which could be deprotection in moderate condition to avoid the isomerization of target molecular. This work not only provides a strategy to approach the total synthesis of pisiferin itself but also serves as an additional correlation origin to which many related icetaxane-type diterpenes can be referred.
Keywords:icetaxane-type diterpenes; Total synthesis; pisiferin; Suzuki coupling; F-C alkylation
 
 
 

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