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Aldehyde Mediated Nitrosation of Amino Acid
YANG Yue 1 #,LIU Zhiying 1,ZHANG Fang 1,TANG Erqing 2,DUAN Jianli 1 *
1.School of Pharmaceutical Sciences, Wuhan University, Wuhan 430072
2.Wuhan University, Wuhan 430072
*Correspondence author
#Submitted by
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Funding: none
Opened online:16 June 2015
Accepted by: none
Citation: YANG Yue,LIU Zhiying,ZHANG Fang.Aldehyde Mediated Nitrosation of Amino Acid[OL]. [16 June 2015] http://en.paper.edu.cn/en_releasepaper/content/4646252
 
 
Everyday humans consume significant quantities of amino acids and sugars. Sugars are the major source of dietary aldehydes. Imines could be produced from the reaction between the amino acid and the sugars under gastric conditions and a possible N-nitroso Amadori comound product could be formed in the endogenous nitrosation process of imines. In this study, nitrosation of the imine salt 19 has been demostrated under the simulated gastric conditions. The resulting N-nitroso Amadori compound 11 was isloated by column chromatography and the 1H NMR and 13C NMR are identical with the standard compound.
Keywords:Nitrosation; Amadori rearrangement; Amino acid; Food; Carcinogenicity基金项目：教育部高等学校博士学科点专项科研基金（20110141120017）；武汉市科技局应用基础研究计划项目（2015060101010031）
 
 
 

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