Efficient pyrido[1,2-a]benzimidazole formation from 2-aminopyridines and cyclohexanones under metal-free conditions

Xie Yanjun; Chen Xiangui; Deng Guojun

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Efficient pyrido[1,2-a]benzimidazole formation from 2-aminopyridines and cyclohexanones under metal-free conditions

Xie Yanjun #,Chen Xiangui,Deng Guojun *

College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105

*Correspondence author

#Submitted by

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Funding: National Natural Science Foundation of China （No.21572194, 21372187）, Hunan Provincial Innovative Foundation for Postgraduate（No.CX2014B258, CX2015B202）, Research Fund for the Doctoral Program of Higher Education of China, Ministry of Education of China（No.20124301110005）

Opened online:23 September 2015

Accepted by: none

Citation: Xie Yanjun,Chen Xiangui,Deng Guojun.Efficient pyrido[1,2-a]benzimidazole formation from 2-aminopyridines and cyclohexanones under metal-free conditions[OL]. [23 September 2015] http://en.paper.edu.cn/en_releasepaper/content/4655112

An efficient procedure for pyrido[1,2-a]benzimidazole preparation from 2-aminopyridines and cyclohexanones under metal-free conditions is described. Iodine could smoothly mediate this kind of transformation without the aid of metal catalyst. Oxygen was used as an environmentally benign oxidant to give the corresponding products in good to high yields. The reaction showed good substrate scope and various functional groups such alkyl, ester, and halogens were well tolerated under the optimized reaction conditions. This method affords an efficient approach for biologically active nitrogen-containing heterocycles using non-aromatic cyclohexanones as the aryl source.

Keywords:organic chemistry; metal-free conditions; high yields; environmentally benign oxidant

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