JIP1 negatively regulates SHIP2 catalytic activity through protein-protein interaction

WU Zhe; XIE Jingwei

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JIP1 negatively regulates SHIP2 catalytic activity through protein-protein interaction

WU Zhe 1,XIE Jingwei 2 * #

1.Department of Neurology, first affiliated hospital, China Medical University, Shenyang,110001

2.Department of pathophysiology, China Medical University, Shenyang, 110122

*Correspondence author

#Submitted by

Subject:

Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.20112104120010）, National Natural Science Funds of China （No.Grant No.81141070）, Liaoning Science&Technology project（No.201225021）, Special financial grant from the China postdoctoral Science foundation （No.201104615）

Opened online:16 November 2015

Accepted by: none

Citation: WU Zhe,XIE Jingwei.JIP1 negatively regulates SHIP2 catalytic activity through protein-protein interaction[OL]. [16 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4660362

SHIP2, a SH2-containing inositol polyphosphate 5-phosphatase 2, plays a role in insulin and growth factor signaling, cytoskeletal organization, neurodegenerative diseases etc. In our previous study, JIP1 (JNK-interacting protein 1) was identified as a new protein partner of SHIP2 and SHIP2 showed negative effect on JIP1-mediated JNK activity. Herein, the region of SHIP2 involved in the interaction with JIP1 and the effect of JIP1 on SHIP2 were inverstigated. Data showd that there existed other region than PR domain of SHIP2 implicating in the association with JIP1, and JIP1 negatively regulated SHIP2 catalytic activity. In addition, SHIP2 might be phosphorylated by JIP1-mediated JNK on serine/threonine sites. Taken together, through JIP1-SHIP2 interaction, JIP1 might be implicated in the signalling functional consequences such as neurodegenerative diseases, cells proliferation and insulin resistance etc.

Keywords:Cell biology, SHIP2, JIP1, protein-protein interaction

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