SHIP2 interacts with MLK3 and regulates its tyrosine phosphorylation

WU Zhe; XIE Jingwei

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

SHIP2 interacts with MLK3 and regulates its tyrosine phosphorylation

WU Zhe 1,XIE Jingwei 2 * #

1.Department of Neurology, first Affiliated hospital, China Medical University, Shenyang, 110001

2.Department of pathophysiology, China Medical University, Shenyang, 110122

*Correspondence author

#Submitted by

Subject:

Funding: Specialized Research Fund for the Doctoral Program of Higher Education（No.20112104120010）, Special financial grant from the China postdoctoral Science foundation （No.201104615）, National Natural Science Funds of China （No.Grant No.81141070）, Liaoning science and technology project （No.201225021）

Opened online:16 November 2015

Accepted by: none

Citation: WU Zhe,XIE Jingwei.SHIP2 interacts with MLK3 and regulates its tyrosine phosphorylation[OL]. [16 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4660744

MLK3, a serine/threonine MAP3K, implicates in various physiological functions as neurodegenerative disease, cell cycle regulation, apoptosis and T-cell activation etc. Phosphorylation of MLK3 is essential for its activation. Ocassionally, in our previous study, MLK3 was found to be phosphorylated at tyrosine site which had not reported yet. Data in the present study show that SHIP2 positively regulated MLK3 tyrosine phosphorylation through SHIP2-MLK3 interaction, and JIP1 showed negative effect on this tyrosine phosphorylation. In addition, SHIP2-MLK3 association was not modulated in response to EGF or TNF-α. Domain tests demonstrate that the catalytic domain of SHIP2 was responsible for the interaction with MLK3. All together, our data may provide a new potential regulating mechaniam of cross-talk between SHIP2 and MLK3-mediated MAPK pathway.

Keywords:cell biology, SHIP2, MLK3, JIP1

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded	42
Bookmarked	0
Recommend	0
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers