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Characterization of Effective Connectivity in Physiology-based Model via Modified Dynamic Causal Model
XIANG Wentao 1,YANG Chunfeng 2 * #,WU Jiasong 3,SHU Huazhong 4,LE BOUQUIN JEANNES Régine 5
1. Laboratory of Image Science and Technology, School of Computer Science and Engineering , Southeast University, Nanjing,210096, China
2. Key Laboratory of Computer Network and Information Integration, Southeast University, Nanjing, 210096, China
3. Université de Rennes 1, LTSI, Rennes, F-35000, France
4. INSERM, U1099, Rennes, F-35000, France
5.Centre de Recherche en Information Biomédicale sino-fran?ais (CRIBs), Nanjing,210096,China
*Correspondence author
#Submitted by
Subject:
Funding: Specialized Research Fund for the Doctoral Program of Higher Education (No.No. 20130092120035 and No. 20120092120036)
Opened online: 1 December 2015
Accepted by: none
Citation: XIANG Wentao,YANG Chunfeng,WU Jiasong.Characterization of Effective Connectivity in Physiology-based Model via Modified Dynamic Causal Model[OL]. [ 1 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4663295
 
 
This paper proposes a new strategy named Modified Dynamic Causal Modelling (MDCM) to detect effective connectivity in an underlying physiology based model aimed at simulating epileptic activities in the hippocampus. The MDCM consists of three parts considering a state-space environment. First of all, an analytical form of the power spectral densities (PSD) as a function of the model parameters is obtained by calculating the transition matrix of the state-space linearized model. Secondly, the PSD are measured from the observed intracerebral electroencephalographic (iEEG) signals, and then the model parameters are estimated by an Expectation Maximum (EM) algorithm. Thirdly, a new estimation of the parameters is obtained using an iterative algorithm and another estimation of the PSD is derived, the most plausible model being finally selected among a set of candidate models. Simulated experimental results indicate that the proposed MDCM outperforms DCM in scenarios of unidirectional flow propagation.
Keywords:epilepsy; physiology based model; iEEG; MDCM; effective connectivity
 
 
 

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