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Fate and Removal of Various Antibiotic Resistance Genes in Typical Pharmaceutical Wastewater Treatment Systems
Zhai Wenchao 1 #,Mao Daqing 2,Luo Yi 1 *
1.College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University, Tianjin, 300071, China
2.School of Environmental Science and Engineering, Tianjin University, Tianjin, 300072, China
*Correspondence author
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Funding: the State Environmental Protection commonweal project （No.201309031)）, the Ministry of Education, People’s Republic of China as an innovative research team project （No.grant No. IRT13024）, National Natural Science Foundation of China （No.Grants 21277075 and 31170472）
Opened online:31 December 2015
Accepted by: none
Citation: Zhai Wenchao,Mao Daqing,Luo Yi.Fate and Removal of Various Antibiotic Resistance Genes in Typical Pharmaceutical Wastewater Treatment Systems[OL]. [31 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4673578
 
 
The high levels of antibiotic residues in pharmaceutical wastewater treatment plants (PWWTPs) make these plants the hotspots for the proliferation of antibiotic resistance genes (ARGs). This study investigated the fate and removal of 11 subtypes ARGs for sulfonamide, tetracycline, β-lactam and macrolide resistance in each stage of two full-scale PWWTPs in northern China. The levels of typical ARG subtypes in the final effluents ranged from (2.56±0.13)×10^1 to (2.36±0.11)×10^7copies/ml. The absolute abundance of ARGs in effluents accounted for only 0.03%-78.1% of influents of the two PWWTPs, while the majority of the ARGs were transported to the dewatered sludge with concentrations from (2.65±0.43)×10^5 to (4.27±0.03)×10^10copies/g dry weight (dw). The total loads of ARGs discharged through dewatered sludge plus effluent was 1.01-14.09 folds higher than that in the raw influents, suggesting the proliferation of ARGs occurred in the wastewater treatment. The proliferation of ARGs mainly occurs in biological treatment process, such as aeration tank, anoxic tank, sequencing batch reactor (SBR) and bio-contact oxidation, facilitates the proliferation of various ARGs, implying significant replication of certain subtypes of ARGs may be attributable to microbial growth. Chemical oxidation seems promising to remove ARGs, with removal efficiency ranged from 29.3% to 85.7%, while the partial correlation analysis showed significant correlations between antibiotic concentration and ARG removal. Thus the high antibiotic residues within the PWWTPs may have an influence on the proliferation, fate and removal of the associated ARG subtypes.
Keywords:antibiotic resistance genes; pharmaceutical wastewater treatment plant; antibiotics; activated sludge; sequencing batch reactor; bio-contact oxidation;
 
 
 

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