Preparation, characterization and antitumor activity of six polysaccharides isolated from natural sources

CEN Yihong; WU Huaping; YAN Xiaorong; Qi Wenwen; GUO Hui; WANG Xiaoqian; XIAO Yuling

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Preparation, characterization and antitumor activity of six polysaccharides isolated from natural sources

CEN Yihong,WU Huaping,YAN Xiaorong,Qi Wenwen,GUO Hui,WANG Xiaoqian,XIAO Yuling *

School of Pharmaceutical Sciences,Wuhan University , Wuhan 430071

*Correspondence author

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Funding: none

Opened online: 2 March 2016

Accepted by: none

Citation: CEN Yihong,WU Huaping,YAN Xiaorong.Preparation, characterization and antitumor activity of six polysaccharides isolated from natural sources[OL]. [ 2 March 2016] http://en.paper.edu.cn/en_releasepaper/content/4678512

The carboxymethylated derivatives of six kinds of polysaccharides isolated from natural Angelica sinensis, Lentinus edodes, Ganoderma lucidum, Poria cocos, Astragalus membranaceus and Maitake were synthesized and characterized. In vitro anti-tumor activity results showed that derivatives of the six polysaccharides showed more effective anti-tumor activities than their original polysaccharides. Also, their water solubility was highly improved. Moreover, Angelica sinensis which showed the best antitumor effect were carboxymethylated with five different degree of carboxymethylation substitution in order to study the correlations between the antitumor activity, the water solubility and the degree of substitution (DS) of the polysaccharide. Experimental results showed that the water solubility of the carboxymethylated derivatives of Angelica sinensis (CASP) was highly improved with increasing of DS. However, the anti-tumor activity was not just enhanced with the increasing of water solubility. A relatively moderate DS (0.187) was found to have the best anti-tumor activities of CASP. Therefore, it can be concluded that carboxymethylation of polysaccharides can effectively enhance their water solubility and in vitro anti-tumor activity.

Keywords:Polysaccharides; Carboxymethylated; Antitumor effect; Water solubility

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