Preventive Effects of Green Tea on Colorectal Cancer: Meta-analysis of Prospective Cohort Study

Fei-Fei Guo*; Yulin Kong*; Bing-Yan Li; Li-Qiang Qin; CL Fu; Zeng-Li Zhang

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Preventive Effects of Green Tea on Colorectal Cancer: Meta-analysis of Prospective Cohort Study

Fei-Fei Guo* #,Yulin Kong*,Bing-Yan Li,Li-Qiang Qin,CL Fu,Zeng-Li Zhang *

School of Public Health of Soochow University, Suzhou, China

*Correspondence author

#Submitted by

Subject:

Funding: none

Opened online:21 April 2016

Accepted by: none

Citation: Fei-Fei Guo*,Yulin Kong*,Bing-Yan Li.Preventive Effects of Green Tea on Colorectal Cancer: Meta-analysis of Prospective Cohort Study[OL]. [21 April 2016] http://en.paper.edu.cn/en_releasepaper/content/4683985

Green tea possibly elicits protective effects against colorectal cancer. Thus, we conducted a meta-analysis of prospective cohort studies to evaluate whether green tea has a preventive effect against colorectal cancer. A systematic literature search was conducted in PubMed. Prospective cohort studies that reported risk ratios (RRs) with 95% confidence intervals (CIs) of colorectal cancer risk of green tea consumption were included. Either a fixed-effects or a random-effects model was used to calculate pooled effects. Combined relative risk (RR) ratios for the highest vs. lowest were calculated. The combined RR derived from 10 cohort studies was 0.89 (95% CI: 0.78-1.00; p<0.001), which show that green tea consumption decreased the risk of colorectal cancer. Subgroup analysis suggested that green tea consumption significantly decreased the risk of colorectal cancer in women(RR, 0.85; 95% CI, 0.72-0.99). In summary, green tea consumption has favorable effects on colorectal cancer, especially in women. However, the result should be interpreted with caution because of the evidence of heterogeneity.

Keywords:green tea;colorectal cancer;meta-analysis

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