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Total Synthesis of Mangiferin, Homomangiferin, and Neomangiferin
WEI Xiong,LIANG Danlin,WANG Qing,MENG Xiangbao,LI Zhongjun * #
The State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191
*Correspondence author
#Submitted by
Subject:
Funding: The National Basic Research Program of China (No.973 Program, Grant No. 2012CB822100), the National Key Technology R&D Program “New Drug Innovation” of China(No.No. 2012ZX09502001-001), the National Research Foundation for the Doctoral Program of Higher Education of China(No.No.20130001110058), the National Natural Science Foundation of China(No.NSFC No. 21232002)
Opened online: 2 August 2016
Accepted by: none
Citation: WEI Xiong,LIANG Danlin,WANG Qing.Total Synthesis of Mangiferin, Homomangiferin, and Neomangiferin[OL]. [ 2 August 2016] http://en.paper.edu.cn/en_releasepaper/content/4701159
 
 
Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum of pharmacological effects, have been achieved starting from 2,3,4,6-tetra-O-benzyl-glucopyranose. The key steps involve a stereoselective Lewis acid promoted C-glycosylation of protected phloroglucinol with tetrabenzylglucopyranosyl acetate and a highly regioselective base-induced cyclization for the construction of the core xanthone skeleton.
Keywords: organic synthesis; mangiferin; neomangiferin; C-glycosyl xanthone; total synthesis
 
 
 

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