Sarcomatoid carcinoma transformation: a rare manifestation of EGFR TKI drug resistance in a patient with lung adenocarcinoma

XU Song; LIU Renwang; LIU Xia; SHI Tao; LI Xiongfei; ZHONG Diansheng; WANG Yan; CHEN Gang; CHEN Jun

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

Sarcomatoid carcinoma transformation: a rare manifestation of EGFR TKI drug resistance in a patient with lung adenocarcinoma

XU Song 1 *,LIU Renwang 2,LIU Xia 3,SHI Tao 2,LI Xiongfei 2,ZHONG Diansheng 3,WANG Yan 3,CHEN Gang 2,CHEN Jun 2

1.Department of Lung Cancer Surgery, Tianjin Medical University General Hospital

2.Department of Lung Cancer Surgery, Tianjin Medical University General Hospital

3.Department of Medical Oncology, Tianjin Medical University General Hospital

*Correspondence author

#Submitted by

Subject:

Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.20131202120004）, National Natural Science Foundation of China （No.81301812）

Opened online:21 April 2017

Accepted by: none

Citation: XU Song,LIU Renwang,LIU Xia.Sarcomatoid carcinoma transformation: a rare manifestation of EGFR TKI drug resistance in a patient with lung adenocarcinoma[OL]. [21 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725568

Objective: Almost all EGFR-mutant lung cancers develop resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs). Several mechanisms for this acquired resistance have been identified, including development of an EGFR T790M mutation, MET amplification, hepatocyte growth factor (HGF) overexpression, loss of PTEN expression, epithelial to mesenchymal transition and transformation to small cell lung cancer. Herein, we presented a lung cancer patient with EGFR exon 19 deltion who was resistant to EGFR TKI treatment. Method: To further explore the underlying mechanisms, we performed a gene mutation profiling by next generation sequencing (NGS). Results: The mechanism of drug resistance is very rare. Some adenocarcinoama cells aquired T790M mutation in EGFR exon 20, and other adenocarcinoama cells transformed into sarcomatoid carcinoma. Conclusion: This case inspires us again the importance of tissue re-biopsy once the acquired resistance occurs after TKI consistant pressure. Sarcomatoid carcinoma transformation is a rare manifestation of EGFR TKI drug resistance in a patient with lung adenocarcinoma.

Keywords:drug resistance; adenocarcinoma; sarcomatoid carcinoma; EGFR-TKI

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded	58
Bookmarked	0
Recommend	0
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers