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An improved predictive assay for radiotherapy to human hepatoma measured by prematurely chromosome condensation technique
Yang Jianshe * #
Institute of Modern Physics, Chinese Academy of Sciences
*Correspondence author
#Submitted by
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Funding: 国家自然科学基金,Pre-studies Subject of National Basic Research Program（No.10335050,2003CCB00200）
Opened online:28 December 2005
Accepted by: none
Citation: Yang Jianshe.An improved predictive assay for radiotherapy to human hepatoma measured by prematurely chromosome condensation technique[OL]. [28 December 2005] http://en.paper.edu.cn/en_releasepaper/content/4728
 
 
To investigate the radiation response of hepatoma, SMMC-7721 cells were irradiated with 60Co γ-rays. Initial chromatid breaks were measured by counting the number of chromatid breaks and isochromatid breaks. A dose-dependent increase in radiation-induced chromatid/isochromatid breaks was observed in G1 and G2 phase respectively. A good relationship was found between cell survival and chromatin breaks. This study implied that low LET radiation-induced chromatid/isochromatid breaks can be possibly used as a good predictor of radiosensitivity of SMMC-7721 hepatoma cells.
Keywords:predictive assay, radiotherapy, hepatoma, prematurely chromosome condensation, technique
 
 
 

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