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| In this paper, on the basis of the special activity of natural rosin derivatives and the good asymmetric induction activity of squaramide organic catalysts, a novel dehydroabietylamine-cinchonine-squaramide catalyst has been developed for asymmetric Michael addition of 2,4-pentanedione to nitroalkenes. It found that with using 5 mol% dehydroabietylamine-cinchonine-squaramide catalyst , the reaction of 2,4-pentanedione to nitroalkenes could act effectively, and a series of nitroalkene derivatives possessing optical activity were afforded with high reaction yields and excellent enantioselectivities (up to 99% yield, 89% ee). |
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| Keywords:Organic chemistry; Dehydroabietylamine-cinchonine-squaramide; Michael addition; Nitroalkenes |
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