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| Diarrhea is a major adverse effect of antibiotic use; however, no known medical regimen is available yet. Glutamine has a pivotal role in intestinal homeostasis, but its implication in antibiotic-associated diarrhea (AAD) remains unclear. Herein we explored the potential of glutamine supplementation in AAD management by using a preclinical mouse model. Data clearly showed that upon clindamycin exposure glutamine store was depleted in colonic mucosa, whereas glutamine supplementation improved several symptoms of experimental AAD. Mechanistically, clindamycin treatment substantially confounded gut microbiota especially in butyrate-producing strains, thereby leads to fecal butyrate deficiency, and in turn increases the body\'s demand for glutamine. Protective effect of glutamine supplementation on AAD may, at least in part, be explained by restoring the intestinal mucosal barrier and facilitating antimicrobial host defense. Taken together, our findings in this study provided a valuable rationale for guiding the clinical uses of glutamine in AAD management. |
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| Keywords:Antibiotic-associated diarrhea; glutamine; intestinal barrier |
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