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The synergistic anti-tumor effects of evodiamine based on animal model experiments: a systematic review and meta analysis
Zheng He,Jiang Li,Pang yunqing,Lv Siyi,Lin Liqi,Wang Jing *
School /Hospital of Stomatology, Lanzhou University, Lanzhou 730000;School /Hospital of Stomatology, Lanzhou University, Lanzhou 730000;School /Hospital of Stomatology, Lanzhou University, Lanzhou 730000;Clinical Research Center for Oral Diseases, Lanzhou 730000;School /Hospital of Stomatology, Lanzhou University, Lanzhou 730000;School /Hospital of Stomatology, Lanzhou University, Lanzhou 730000;School /Hospital of Stomatology, Lanzhou University, Lanzhou 730000;Clinical Research Center for Oral Diseases, Lanzhou 730000
*Correspondence author
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Funding: the National Natural Science Foundation of China （No.81773942）, the Scientific and Technological Foundation of Gansu Province （No.21JR1RA112)）, the School/Hospital of Stomatology Lanzhou University （No.lzukqky-2020-y03）
Opened online:18 April 2022
Accepted by: none
Citation: Zheng He,Jiang Li,Pang yunqing.The synergistic anti-tumor effects of evodiamine based on animal model experiments: a systematic review and meta analysis[OL]. [18 April 2022] http://en.paper.edu.cn/en_releasepaper/content/4757287
 
 
Evodiamine (EVO) is an alkaloid extracted from the dried and nearly ripe fruits of Euodia rutaecarpa used as an anti-cancer, anti-inflammatory and anti-obesity agent. However, robust evidence of preclinical experiments has been lacking so far. As a consequence, a systematic review and meta-analysis was conducted to assess the anti-tumor effect of evodiamine combined therapy. The search engine and electronic databases includes PubMed, Scopus, China Knowledge Resource Integrated Database (CNKI) and SinoMed. Stata 15.0 was used for data extraction. Tumor volume and tumor weight were evaluate at a 95% confidence level using random effects model. Begg\'s test and funnel plot were used for the evaluation of publication bias. Sensitivity analysis is used to investigate the stability of results.A total of 7 studies and 108 animals were included. Overall, EVO reduced tumor volume(SMD=-25.64,95% CI: -5.77 -3.13,I2=92.5%, P<0.05) and tumor weight(SMD=-8.91,95% CI: -16.37, -1.44,I2=94.1%, P<0.05). As a result, EVO combined therapy appears to be more effective compared with monotherapy. Moreover, EVO has a potential to alleviate the toxicity of chemotherapeutic agents, which increases the translatability to the clinical situation.
Keywords:evodiamine; combined therapy; animal model experiment; meta-analysis; systematic review
 
 
 

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