Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors

Jun ZHANG; Han Xiaohu; Li Hongzhao; Zhu Jingning; Jian-Jun Wang

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Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors

Jun ZHANG,Han Xiaohu,Li Hongzhao,Zhu Jingning,Jian-Jun Wang * #

Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences，Nanjing University

*Correspondence author

#Submitted by

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Funding: 国家自然科学基金,教育部博士点基金,江苏省自然科学基金（No.30370462，30670671，30700201,20050284025，20070284057,BK2006713）

Opened online: 9 January 2009

Accepted by: none

Citation: Jun ZHANG,Han Xiaohu,Li Hongzhao.Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors[OL]. [ 9 January 2009] http://en.paper.edu.cn/en_releasepaper/content/27566

Through whole-cell patch recordings in brainstem slices, the effects of histamine on neuronal activity of the lateral vestibular nucleus (LVN) were investigated. Bath application of histamine elicited a concentration-dependent excitation of both spontaneous firing (n = 19) and silent (n = 7) LVN neurons. Moreover, histamine induced a stable inward current in the LVN neurons (n = 5) and the histamine-induced depolarization of membrane potential persisted in the presence of tetrodotoxin (n = 4), indicating a direct postsynaptic effect of the histamine on the LVN neurons. Selective histamine H2 receptor antagonist ranitidine effectively blocked the histamine-evoked excitatory responses on the LVN neurons (n = 4), but selective histamine H1 receptor antagonist triprolidine did not (n = 4). In addition, selective histamine H2 receptor agonist dimaprit (n = 3) rather than 2-pyridylethylamine (n = 4), a selective histamine H1 receptor agonist, mimicked the excitatory action of histamine on LVN neurons. The results demonstrate that histamine excites the LVN neurons via postsynaptic histamine H2 receptors and suggest that the central histaminergic projection arising from the hypothalamus may modulate LVN neurons activity and actively influence the vestibular reflexes and functions.

Keywords:histamine; lateral vestibular nucleus; H2 receptors; motor control

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