Histamine excites neurons of the inferior vestibular nucleus in rats by activation of H1 and H2 receptors

PENG Shiyu; ZHUANG Qianxing; HE Yecheng; ZHU Jingning; WANG Jianjun

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Histamine excites neurons of the inferior vestibular nucleus in rats by activation of H1 and H2 receptors

PENG Shiyu,ZHUANG Qianxing,HE Yecheng,ZHU Jingning *,WANG Jianjun * #

School of Life Sciences, Nanjing University, NanJing 210093

*Correspondence author

#Submitted by

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Funding: NCET Program（No.20100091110016）, Fundamental Research Funds for the Central Universities（No.1094020806，1095020821）, NCET Program, and Fundamental Research Funds for the Central Universities（No.30931160433）, the Natural Science Foundation of Jiangsu Province, China（No.BK2011014）, NSFC/RGC Joint Research Scheme 30931160433 from the National Natural Science Foundation of China（No.31070959, 31071021,31171050）

Opened online: 5 March 2013

Accepted by: none

Citation: PENG Shiyu,ZHUANG Qianxing,HE Yecheng.Histamine excites neurons of the inferior vestibular nucleus in rats by activation of H1 and H2 receptors[OL]. [ 5 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4523979

By using brain slice preparations and extracellular recordings, the effect of histamine on spontaneous firing activities of neurons in the inferior vestibular nucleus (IVN), a key structure responsible for integration of vestibular, multisensory, and cerebellar inputs, in rats was investigated. Perfusing slices with histamine (1-10 μM) elicited an excitatory response on IVN neurons. The responses were not blocked by low Ca2+/high Mg2+ medium, indicating a direct postsynaptic effect of the amine. Furthermore, the histamine-induced excitation was partially blocked by selective histamine H1 receptor antagonist mepyramine (1 μM) and H2 receptor antagonist ranitidine (1 μM), respectively. Co-application of mepyramine and ranitidine nearly totally antagonized the histamine-induced excitation. Additionally, both selective H1 receptor agonist 2-pyridylethylamine (30-300 μM) and H2 receptor agonist dimaprit (10-100 μM) effectively mimicked the excitatory action of histamine on IVN neurons. Moreover, selective H4 antagonist JNJ7777120 (10 μM) and agonist VUF8430 (30-300 μM) had no effect on IVN neurons. These results demonstrate that histamine excites IVN neurons via postsynaptic H1 and H2 rather than H4 receptors, and suggest that the central histaminergic system actively modulate all four major vestibular nuclei including the IVN and may subsequently influence the vestibular nuclei-related reflexes and functions.

Keywords:Histamine; Inferior vestibular nucleus; Histamine receptors; Vestibular reflexes

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