Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells

guifa li; yuxiangjiang; dongchen; wiwang; yukuncui; fukunzhao

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Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells

guifa li 1 * #,yuxiangjiang 1,dongchen 1,wiwang 1,yukuncui 2,fukunzhao 1

1.Life science college Zhejiang Sci-Tec University

2.Breast Center Baylor College of MedicineOne Baylor Plaza One Baylor Plaza

*Correspondence author

#Submitted by

Subject:

Funding: none

Opened online:23 February 2009

Accepted by: none

Citation: guifa li,yuxiangjiang,dongchen.Using Mammospheres as a Model to Determine Protein Signatures Presented in Breast Cancer Stem Cells[OL]. [23 February 2009] http://en.paper.edu.cn/en_releasepaper/content/29434

The breast cancer stem cells have been proposed to underpin many types of breast Cancer. also,mammospheres have been widely employed to study breast cancer stem cells. In current study, we have used the approaches of Proteomics to study the altered protein expression in mammospheres from the most commonly used breast cancer cell line MCF-7. we have identified 34 differentially expressed proteins in Mammospheres from parental cells. Of these 34 proteins, only seven expressed higher in Mammosheres. We find that FKBP4 and GIPC1 which is high associated with insulin-like growth factor I receptor was low expressed in mammospheres. The two proteins and their implications in breast cancer drug resistance are currently under study in our laboratory.

Keywords:breast cancer;mammosphere;cancer stem cells;2-DE;MS

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