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Exo-Selective Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with Alkylidene Malonates Catalyzed by AgOAc/TF-BiphamPhos
Yong Xuezhi,Liu Tanglin,Lu Zhou ,Huang He ,Tao Haiyan ,Wang Chunjiang * #
College of Chemistry and Molecular Sciences, Wuhan University, 430072, China
*Correspondence author
#Submitted by
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Funding: none
Opened online: 5 February 2010
Accepted by: none
Citation: Yong Xuezhi,Liu Tanglin,Lu Zhou .Exo-Selective Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with Alkylidene Malonates Catalyzed by AgOAc/TF-BiphamPhos[OL]. [ 5 February 2010] http://en.paper.edu.cn/en_releasepaper/content/39977
 
 
The first catalytic enantioselective 1,3-dipolar cycloaddition of various alkylidene malonates with azomethine ylides has been developed. The highly efficient AgOAc/TF-BiphamPhos catalytic system shows excellent performance, providing exo-adducts of polysubstituted pyrrolidine derivatives in good yields, excellent diastereoselectivities and good enantioselectivities
Keywords:asymmetric catalysis;1,3-dipolar cycloaddition;alkylidene malonates;azomethine ylides
 
 
 

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