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RNAi-mediated Knockdown of Notch-1 Leads to Cell Growth Inhibition and Enhanced Chemosensitivity in Human Breast Cancer
Zang Shaolei ,Chen Feng ,Ji Chunyan
Department of Hematology,Qilu Hospital, Shandong University
*Correspondence author
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Funding: 国家自然基金,国家自然基金,教育部博士点基金,山东省科技厅,山东省科技厅（No.30871088,30471941,20060422051,2005GG4202018,03BS025）
Opened online: 9 February 2010
Accepted by: none
Citation: Zang Shaolei ,Chen Feng ,Ji Chunyan .RNAi-mediated Knockdown of Notch-1 Leads to Cell Growth Inhibition and Enhanced Chemosensitivity in Human Breast Cancer [OL]. [ 9 February 2010] http://en.paper.edu.cn/en_releasepaper/content/40114
 
 
Notch signaling plays a critical role in determining cell fate such as proliferation, differentiation, and apoptosis. Accumulating evidences indicate that aberrant Notch signaling has tumor-promoting function in breast cancers. We hypothesized that Notch signaling may be a potential therapeutic target for human breast cancer. To address this issue, we down-regulated the expression of the Notch-1 receptor by siRNA in human breast cancer cells. We found that the down-regulation of Notch-1 signaling caused cancer cell growth inhibition by apoptosis induction. The effect of the down-regulation of Notch-1 may be through the inactivation of NF-κB. In addition, the down-regulation of Notch-1 signaling increased chemosensitivity to doxorubicin and docetaxel. Our results suggested that Notch signaling may be a promising target for breast cancer treatment.
Keywords:Notch signaling;breast cancer;RNA interference;proliferation;chemosensitivity
 
 
 

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