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| Human have different hemopoietic organs at different times, such as fetal liver, thymus, lymph node and bone marrow, etc. In this study, we analyzed their expression profilings by GO and hierarchical cluster to understand their developmental mechanisms and mutual relations. Results: (1) GO classification showed that they are divided into 1045 categories. (2) The expression activities are: fetal liver > bone marrow > thymus > lymph node. (3) The specific genes of fetal liver, thymus, bone marrow and lymph node are 953, 175, 102 and 52, most of these genes have more relations with their respective physiological functions. (4) Hierarchical clustering analysis illustrated the relations among thymus, lymph node and bone marrow are closer than them with fetal liver. Discusses: GO classification still needs to develop newer methods to improve applicability, and hemopoietic cell are apt to transfer to lymphoid organs, or lymphoid organs and hemopoietic organs essentially come from same ancestor. |
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| Keywords:bioinformatics;human hemopoietic tissues;expression profile;gene ontology;hierarchical cluster |
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