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Interaction of tamoxifen citrate with salmon sperm DNA and bovine serum albumin
Zhu Ling #,Liu Xiaoyan,Zhang Haixia *
State Key Laboratory of Applied Organic Chemistry, Lanzhou University
*Correspondence author
#Submitted by
Subject:
Funding: The Program for New Century Excellent Talents in University （No.NCET-07-0400）, The National Natural Science Foundation of China Fund （No.No.20775029, J0730425）
Opened online:26 July 2010
Accepted by: none
Citation: Zhu Ling,Liu Xiaoyan,Zhang Haixia.Interaction of tamoxifen citrate with salmon sperm DNA and bovine serum albumin[OL]. [26 July 2010] http://en.paper.edu.cn/en_releasepaper/content/4379564
 
 
Interaction of tamoxifen citrate (TC) with salmon sperm DNA and bovine serum albumin (BSA) were investigated by various spectroscopic analysis methods under simulative physiological conditions. Thermodynamic parameters showed that the interaction process was spontaneous and hydrophobic forces play a major role in the binding between BSA and TC. The quenching constant KSV, the bimolecular quenching constant kq and the numbers of binding sites n (about 1) of both DNA and BSA to TC were similar. The value of n approximately equal to 1 indicated that there is only one type of binding site for DNA or BSA to TC. However, the binding constant (K) of DNA to TC was lower than that of BSA.
Keywords:Tamoxifen citrate; salmon sperm DNA; bovine serum albumin; spectroscopic
 
 
 

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