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Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with N-Tosyl Imines Using Copper(I)/TF-BiphamPhos Complex
Liang Gang,Tong Minchao,Tao Haiyan,Wang Chunjiang * #
Wuhan University, College of Chemistry and Molecular Sciences
*Correspondence author
#Submitted by
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Funding: SRFDP(No.20090141110042), National Natural Science Foundation of China (No.20642005, 20702039, 20972117)
Opened online: 9 August 2010
Accepted by: none
Citation: Liang Gang,Tong Minchao,Tao Haiyan.Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with N-Tosyl Imines Using Copper(I)/TF-BiphamPhos Complex[OL]. [ 9 August 2010] http://en.paper.edu.cn/en_releasepaper/content/4380685
 
 
In this paper, the direct asymmetric Mannich reaction of glycine Schiff base with N-tosyl imines has been developed with Cu(CH3CN)4BF4/TF-BiphamPhos complex. This catalytic system performances well over abroad scope of substrates, furnishing anti-adducts of various a-diamino acid esters in good yields with up to 94:6 diastereoselectivity and 97% enantioselectivity.
Keywords:asymmetric catalysis; Mannich reaction;glycine Schiff base; N-tosyl imine;diastereoselectivity;enantioselectivity
 
 
 

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