Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles

Fang Dan; Cao Ying; Yang Lin; Wang Kui; Wang Huajie

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Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles

Fang Dan,Cao Ying,Yang Lin * #,Wang Kui,Wang Huajie

College of Chemistry and Environmental Science, Henan Normal University

*Correspondence author

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Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.No. 20070476001）, the National Key Basic Research and Development Program of China （No.No. 2009CB626610）, the National Science Foundation of China（No.No. 20771036 and 20971039）

Opened online: 1 December 2010

Accepted by: none

Citation: Fang Dan,Cao Ying,Yang Lin.Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles[OL]. [ 1 December 2010] http://en.paper.edu.cn/en_releasepaper/content/4392328

Controllable synthesis of hydroxyapatite with different size and morphology has drawn more and more attention these days due to the Size/morphology-dependent cytotoxicity of hydroxyapatite in tumor treatments. In this study, a facile method was developed for the controllable synthesis of bovine serum albumin-conjugated micro- and nano- hydroxyapatite. Scanning electron microscope, Fourier transform infrared, energy dispersive system analysis and X-ray powder diffraction displayed that the pH value was the key factor affecting the morphology, size and crystal structure of products. The optimal pH value for the flocculatidn hydroxyapatite micro-crystals with size 1.82 ± 0.19 μm in the diameter and amorphous hydroxyapatite nanoparticles with size 167 ± 12 nm in the diameter was 7.97 and 6.5, respectively.

Keywords:Biomineralization; Controllable synthesis; Hydroxyapatite

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