| |
| In this paper，The PU scaffold was fabricated with aliphatic isophorone diisocyanate (IPDI) as hard segment and glyceride of castor oil as soft segment. The n-HA/PU composite scaffolds were developed by in situ polymerization. The obtained PU and n-HA/PU composite scaffolds were characterized by FTIR, and SEM. The mechanical property and porosity were tested. The results showed that the characteristic absorption peak of n-HA and PU were presented in FTIR spectra of n-HA/PU composites. The porosity of PU, n-HA/PU composite with 20 wt% n-HA and n-HA/PU composite with 40 wt% n-HA were 61±3%, 68±2% and 57±3%, respectively. The compressive strength of above three porous scaffolds was 605±61 KPa, 2125±58 KPa and 4588±257 KPa, respectively. To evaluate the cytocompatibility of porous scaffolds, the MG63 cells were seeded on scaffolds. The scaffold contained n-HA were more helpful for cell adhesion, spread and proliferation in 3D cultivation. It is believed that n-HA/PU composite porous scaffolds developed in this study have the potential to be applied in bone reconstruction and repair. |
|
| Keywords:porous scaffold for tussiue engineering；polyurethane；nano-hydroxyapatite；cytocompatibility |
|
