Detection of microRNA with low abundance in serum of schizophrenia patients

Shi Wenting; Du Jinglun; Qi Yuhua; Liang Gaofeng; Wang Tianyu; Li Shuchun; Yang Ke; Xie Shiping; Xiao Zhongdang

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Detection of microRNA with low abundance in serum of schizophrenia patients

Shi Wenting 1 * #,Du Jinglun 2,Qi Yuhua 1,Liang Gaofeng 1,Wang Tianyu 2,Li Shuchun 1,Yang Ke 1,Xie Shiping 2,Xiao Zhongdang 1

1.State Key Laboratory of Bioelectronics, School of biological Science and Medical Engineering, Southeast University

2.Department of psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University

*Correspondence author

#Submitted by

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Funding: none

Opened online: 2 December 2010

Accepted by: none

Citation: Shi Wenting ,Du Jinglun ,Qi Yuhua .Detection of microRNA with low abundance in serum of schizophrenia patients[OL]. [ 2 December 2010] http://en.paper.edu.cn/en_releasepaper/content/4393256

Recent studies have revealed that aberrant expression of serum miRNA can directly reflect disease status. However, the study of serum miRNA for schizophrenia has not been reported so far. In this paper, the expression levels of serum miR-346 which is the most promising miRNAs to reflect schizophrenia status are studied. Semi-nested qRT-PCR was developed to detect miR-346 with very low abundance in serum sensitively and specifically. The results showed that the expression levels of miR-346 were significantly higher in schizophrenia patients than those in normal subjects. Compared with family schizophrenia patients, circulating miR-346 was significantly higher in sporadic schizophrenia, indicating that there is a positive correlation of circulating miRNA-346 level between schizophrenia patients with and without family history.

Keywords:schizophrenia; miR-346; serum; semi-nested qRT-PCR

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