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| Aim of the study: This is a study aiming to evaluate the structural elements essential to the antidiabetic activity of flavonoids. Methods: We synthesized two series of flavonoids, 5,7-dihydroxyflavanones and 5,7-dihydroxyflavones. Results: In a screening for in vitro potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 5f, 7d, and 10c were significantly more effective than the positive control, metformin. Conclusion: The biological activity was mainly affected by introducing structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7-dihydroxyflavonoids can be considered promising candidates in the development of new antidiabetic lead compounds. |
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| Keywords:Flavonoids; 5,7-Dihydroxy; Antidiabetic activity |
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