Novel alginate coated hydrophobically modified chitosan polyelectrolyte complex nanoparticles for the delivery of BSA

CHEN Lili; GUO Ri; CAI Shushan; LIU Zonghua; ZHU Yi; ZHANG Yuanming

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Novel alginate coated hydrophobically modified chitosan polyelectrolyte complex nanoparticles for the delivery of BSA

CHEN Lili 1 #,GUO Ri 2,CAI Shushan 1,LIU Zonghua 2,ZHU Yi 1,ZHANG Yuanming 1 *

1.Department of Chemistry, Jinan University, Guangzhou 510632, China

2.Institutes of Life and Health Engineering, Jinan University , Guangzhou 510632,China

*Correspondence author

#Submitted by

Subject:

Funding: Natural Science Foundation of Guangdong （No.Grant No. 10151063201000010）

Opened online: 2 March 2012

Accepted by: none

Citation: CHEN Lili,GUO Ri,CAI Shushan.Novel alginate coated hydrophobically modified chitosan polyelectrolyte complex nanoparticles for the delivery of BSA[OL]. [ 2 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4466980

Polysaccharides based polyelectrolyte complex nanoparticles (PCNs) intended for use in the delivery of macromolecules were prepared by the self-assembly of deoxycholic acid hydrophobically modified chitosan (CS-DCA) core and then coated with sodium alginate (ALG) shell. The CS-DCA capable of forming nano-sized self-aggregates in medium was prepared by the grafting of DCA to CS. In order to increase the stability of nanoparticles and prevent burst release of drug in bloodstream, polyanionic ALG was coated on the surface of positively charged self-aggregated chitosan nanoparticles to form PCNs. Dynamic light scattering (DLS) results revealed that the mean diameter of the PCNs was about 330 nm, larger than that of uncoated nanoparticles (~150 nm). The zeta potential was big enough to keep the stability of PCNs (28 mV); no size change was found even upon 1 month storage. Bovine serum albumin (BSA) could be easily incorporated into the PCNs with encapsulation efficiency (~ 69%) and keep a sustained manner without burst release when exposed to PBS (pH 7.4). These results suggested that PCNs may be a promising drug carrier for a prolonged and sustained delivery in the bloodstream.

Keywords: chitosan-deoxycholic acid; alginate; polyelectrolyte complexes nanoparticles; drug delivery

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