Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy

DING Zhenyu; ZHAN Hong; BIRGIT Olsson; Gunnar Adell; SUN Xiaofeng

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Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy

DING Zhenyu 1 * #,ZHAN Hong 2,BIRGIT Olsson 3,Gunnar Adell 4,SUN Xiaofeng 5

1.Cancer Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University, ChengDu 610041

2.University of Skoveda, Sweden, S85185

3.University of Linkoping

4.University of Linkoping, Sweden, S58185

5.University of Linkoping, Sweden. S58185

*Correspondence author

#Submitted by

Subject:

Funding: Doctoral Fund of Ministry of Education of China（No.20090181120100）, National Natural Science Fund of China （No.30901756）

Opened online:28 December 2012

Accepted by: none

Citation: DING Zhenyu,ZHAN Hong,BIRGIT Olsson.Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy[OL]. [28 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4504253

Purpose To investigate the expression significance of Livin in relation to radiotherapy (RT), clinicopathological, and biologicalprognostic factors of rectal cancer patients. Methods We included 144 primary rectal cancer patients who participated in a Swedish clinical trial of preoperative radiotherapy. Tissue microarray samples from the excised primary rectal cancers, and the adjacent andor distant normal mucosa and lymph node metastases were immunostained with Livin antibody. Survival probability was computed by the Kaplan-Meier method and Cox regression model. The proliferation of colon cancer cell lines SW620 and RKO was assayed after Livin knock-down. Results The expression of Livin was significantly increased from adjacent (P=0.051) or distant (P=0.028) normal mucosa to primary tumors. The frequency of Livin-positive expression in primary cancers was decreased with preoperative RT (from 97% to 83%, P=0.004). The expression of Livin was associated with lower frequency of stage I and higher frequency of stage II, III or IV cases (P=0.044), and related to poor differentiation of cancers (P=0.033). The positivenegative expression of Livin was associated with advancedearlier TNM stage and worsegood differentiedation of tumors (after you change the result re-write this part). The survival rate of the patients with Livin-positive tumors tended to be lower than that those with Livin-negative tumors (P=0.091). In multivariate analyses, Livin expression predictated poor survival (odds ratio=5.09, 95%CI: 1.01-25.64, P=0.048) independent on TNM stage, local and distant recurrence, grade of differentiation, gender, and age. In the current study, the median overall survival was similar between patients with (129 months) or withourt (114 months) preoperative RT (P=252). In the in vitro study, SW620 and RKO cells with Livin knock-down exhibited significant decrease in proliferation compared scramble siRNA treated controls after RT. Conclusions The expression of Livin was related to the higher frequency of advanced stage of cancer. Livin expression was independently related to survival in rectal cancer patients. The preoperative RT had no influence on the survival. Our data implicated Livin as a useful prognostic factor for rectal cancer patients and possibly served as a potential therapeutic target. Livin positive expression was related to the more advanced stage of cancer. Livin expression was independently related to survival in rectal cancer patients. Our data implicated Livin was a useful prognostic factor for rectal cancer patients and possibly served as a potential therapeutic target.

Keywords:Oncology; Livin; colon cancer; radiotherapy

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