Expression of different POT1 variant is Associated with Telomere Length and radiosensitivity in Colon and Gastric Adenocarcinoma cells in vitro

Lei Han; Tian Muyou; Zhong Yahua; Zhou Fuxiang; Xie Conghua; Zhou Yunfeng; Liao Zhengkai

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Expression of different POT1 variant is Associated with Telomere Length and radiosensitivity in Colon and Gastric Adenocarcinoma cells in vitro

Lei Han 1,Tian Muyou 2,Zhong Yahua 3,Zhou Fuxiang 1,Xie Conghua 2,Zhou Yunfeng 3,Liao Zhengkai 1 *

1.Hubei Cancer Clinical Study Center

2. Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University

3. Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University

*Correspondence author

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Funding: National Natural Science Foundation of China （No.No. 30800278）, Doctoral Fund of Ministry of Education of China （No.Youth Scholars）

Opened online:10 March 2014

Accepted by: none

Citation: Lei Han,Tian Muyou,Zhong Yahua.Expression of different POT1 variant is Associated with Telomere Length and radiosensitivity in Colon and Gastric Adenocarcinoma cells in vitro[OL]. [10 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4587832

Protection of telomeres 1 (POT1) is a telomere-binding protein, which binds to the single-stranded DNA extensions of telomeres and regulates telomere length. Different POT1 mRNA variants were examined and compared with telomere length and radiosensitivity in Colon and Gastric Adenocarcinoma cells. POT1 production and telomere lengths were assessed in 10 human cancer cell lines by Real-time quantitative RT-PCR, respectively. POT1 mRNA levels, which were relatively stable, were significantly correlated with telomere length in gastric cancer cells and colon cancer groups excluding the HT29 with low telomerase activity (P<0.01). Meanwhile, POT1 v5 indexes were correlated with radiosensitivity in both colon cancer cells or gastric cancer cells (P<0.05). Pot1 might be a good marker for the examination of cell-specific telomere length and radiosensitivity. In this report, we identi?ed a key role for POT1 in the maintenance of telomeric single-stranded tails as well as DNA damage protective functions.

Keywords:POT1 variant; telomere length; radiosensitivity; chromosome protection

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