Identification of the subtype diversity of genotype 4 hepatitis E virus in eastern China

ZHANG Wen; TIAN Hua; YANG Shixing; FU Xingli; LI Wang; HUANG Yuan; SUN Jiayao; ZHOU Gai; ZHOU Chenglin; SHEN Quan

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Identification of the subtype diversity of genotype 4 hepatitis E virus in eastern China

ZHANG Wen 1 * #,TIAN Hua 2,YANG Shixing 1,FU Xingli 1,LI Wang 1,HUANG Yuan 1,SUN Jiayao 1,ZHOU Gai 1,ZHOU Chenglin 1,SHEN Quan 1

1.School of Medicine, Jiangsu University, Zhenjiang, 212013

2.Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing 210009, China

*Correspondence author

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Funding: Jiangsu University Research Project for Undergraduate （No.No. 12A125, 12A126, and 12A193）, The Ph.D. Programs foundation of Ministry of Education of China （No.No. 20113227120008）

Opened online:17 November 2014

Accepted by: none

Citation: ZHANG Wen,TIAN Hua,YANG Shixing.Identification of the subtype diversity of genotype 4 hepatitis E virus in eastern China[OL]. [17 November 2014] http://en.paper.edu.cn/en_releasepaper/content/4616844

Hepatitis E viruses (HEVs), a zoonotic pathogen, use several species of animal as reservoirs. Swine is considered as the major reservoir for HEV infection in humans. Genotype 4 HEV is the dominant cause of hepatitis E disease in humans in China. Several recent studies showed that genotype 4 HEV is transmitted between humans and swine in China. In the present study, a total of 125 anti-HEV IgM positive human serum and 290 swine fecal samples were subjected to RT-PCR screening of HEV RNA. Results indicated 24 human serum samples were positive, while 9.66% (28/290) of the 290 swine fecal samples were positive for HEV RNA. Phylogenetic analysis based on partial capsid gene showed that the 51 HEV strains in the current study all belonged to genotype 4, clustering into 6 different subtypes. Some of HEV isolates prevalent in the human and swine populations were classified into the same clusters, suggesting that cross-species transmission occurred. Our study revealed the subgenotype diversity of genotype 4 HEV in eastern China.

Keywords:Hepatitis E virus; Subtype; Phylogenetic analysis

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