Buyang-Huanwu decoction blocks TGF-β/Smad pathway by inhibiting FUT8 expression in IRI mice

WEN Qingsi; GUAN Qing; ZHOU Yue; SHI Yan; SUN Yu; YAN Zewen; LIN Hongli; WANG Dapeng

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Buyang-Huanwu decoction blocks TGF-β/Smad pathway by inhibiting FUT8 expression in IRI mice

WEN Qingsi 1,GUAN Qing 2,ZHOU Yue 2,SHI Yan 2,SUN Yu 2,YAN Zewen 2,LIN Hongli 2 *,WANG Dapeng 2

1.Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China;Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China;Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China;Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China;Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China;Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China;Department of Nephrology, The First Affiliated Hospital, Dalian Medical University, Dalian,Liaoning,116011, China;Department of Nephrology, The First Affiliated Hospital, Dalian Medical University, Dalian,Liaoning,116011, China

*Correspondence author

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Funding: none

Opened online: 8 April 2024

Accepted by: none

Citation: WEN Qingsi,GUAN Qing,ZHOU Yue.Buyang-Huanwu decoction blocks TGF-β/Smad pathway by inhibiting FUT8 expression in IRI mice[OL]. [ 8 April 2024] http://en.paper.edu.cn/en_releasepaper/content/4762419

In order to elucidate the mechanism of Buyang-Huanwu decoction in TGF-β/Smad signaling pathway in AKI-to-CKD mice. We constructed animal model of AKI-to-CKD by renal ischemia-reperfusion injury (IRI). We grouped the mice, assessed renal function on the 30th day after modeling, tested the level of α-SMA and TGF-β/Smad pathways, and detected the changes of Fut8 and VEGF R2 levels and core fucosylation of TGF-βRⅡ. The results show that Buyang-Huanwu decoction also down-regulates the level of Fut8 and core fucosylation of TGF-βRII, up-regulates the level of VEGF R2, inhibits the activation of TGF-β/Smad, and eases the process of IRI. These data indicate that Buyang-Huanwu decoction could inhibit the activation of TGF-β/Smad pathway by inhibiting the Fut8 and then block the pathological process of AKI-to-CKD.

Keywords: Buyang-Huanwu decoction; AKI-to-CKD; TGF-β/Smad; Fut8; IRI; core fucosylation 注：本文WEN Qingsi和GUAN Qing为共一作

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