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Hyperactivated uterine NK cells contribute more for the regulation of murine pregnancy
Zhang Jianhong 1,Sun Rui 2,Wei Haiming 3,Wu Dongmei 3,Tian Zhigang 3 #
1.Institute of Immunology, School of Life Sciences, University of Sciences and Technology of China
2.Institute of Immunology, School of Life Sciences, University of Sciences and Technology of
3.Institute of Immunology- School of Life Sciences, University of Sciences and Technology of China
*Correspondence author
#Submitted by
Subject:
Funding: 教育部博士点基金(No.20030358044)
Opened online:14 November 2006
Accepted by: none
Citation: Zhang Jianhong,Sun Rui,Wei Haiming.Hyperactivated uterine NK cells contribute more for the regulation of murine pregnancy[OL]. [14 November 2006] http://en.paper.edu.cn/en_releasepaper/content/9532
 
 
To understand the response of murine uterine natural killer (uNK) cells to Toll-like receptor (TLR) 3 agonist at the early stage of gestation, CBA×DBA/2 mice were intraperitoneally (i.p.) injected with polyinosinic-polycytidylic acid (poly I:C), the specific TLR-3 agonist, at dose of 10 μg/g·BW or PBS at gestation day (gd) 6.5. The percentage of intracellular TNF-α+ or IFN-γ+ uNK (DX5+CD3-) cells in the implantation sites of CBA×DBA/2 matings were significantly increased 24 hours after poly I:C injection. Surprisingly, poly I:C treatment significantly decreased the total number of uNK cells (either DX5+CD3- or DBA+) at fetal maternal surface, but had no influence on local NKT cells, T cells and DCs. This investigation will help to explain the central role for hyperactivated uNK cells in the progress of mice pregnancy.
Keywords:Polyinosinic-polycytidylic acid; Uterine natural killer cells; IFN-γ; TNF-α
 
 
 

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