Aberrant Expression of ZNF268 Alters the Growth and Migration of Ovarian Cancer Cells

HU Li; WANG Wei; CAI Jinyang; LUO Jun; HUANG Yi; XIONG Shilu; LI Wenxin; GUO Mingxiong

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Aberrant Expression of ZNF268 Alters the Growth and Migration of Ovarian Cancer Cells

HU Li 1,WANG Wei 1,CAI Jinyang 1,LUO Jun 2,HUANG Yi 3,XIONG Shilu 3,LI Wenxin 1,GUO Mingxiong 1 *

1.College of Life Sciences, Wuhan University

2.Department of Pathology, Zhongnan Hospital, Wuhan University

3.Department of Gynecologic Oncology, Hubei Cancer Hospital

*Correspondence author

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Funding: This work was supported by National High Technology Research and Development Program of China （No.863 Program) Grant）

Opened online: 7 January 2013

Accepted by: none

Citation: HU Li,WANG Wei,CAI Jinyang.Aberrant Expression of ZNF268 Alters the Growth and Migration of Ovarian Cancer Cells[OL]. [ 7 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4509597

Ovarian cancer is one of the most lethal gynaecologic cancers worldwide. However, the mechanism underlying ovarian carcinogenesis is not well understood. Here, we show that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268 knockdown increased the viability, colony formation, and the growth of in vivo xenografts of ovarian carcinoma SKOV-3 cells, whereas SKOV-3 cell migration was inhibited by ZNF268 knockdown. Furthermore, we demonstrated that ZNF268 knockdown may increase SKOV-3 cell growth by promoting cell cycle progression. Our findings suggest that ZNF268 is a novel protein involved in ovarian carcinogenesis and may help us better understand the mechanism of ovarian carcinogenesis.

Keywords:ZNF268; Ovarian cancer; SKOV-3 cells

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