High-performance Single Compound Multifunctional Agents: Rapid Ligand-Exchange Strategy, Enhanced Dual-modality MR Contrast and Magnetic Hyperthermia

HAO Rui; YU Jing; GE Zigang; ZHAO Lingyun; SHENG Fugeng; XU Lili; LI Gongjie; HOU Yanglong

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High-performance Single Compound Multifunctional Agents: Rapid Ligand-Exchange Strategy, Enhanced Dual-modality MR Contrast and Magnetic Hyperthermia

HAO Rui 1,YU Jing 1,GE Zigang 2,ZHAO Lingyun 3,SHENG Fugeng 4,XU Lili 4,LI Gongjie 4,HOU Yanglong 1 *

1.Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871

2.Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871

3.Institute of Medical Physics, Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084

4.Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing 100071

*Correspondence author

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Funding: This work was supported in part by the NSFC （No.51125001, 51172005, 90922033 and 21105120）, the Natural Science Foundation of Beijing（No.2122022）, the Doctoral Program of the Education Ministry of China（No.20120001110078）

Opened online: 1 March 2013

Accepted by: none

Citation: HAO Rui,YU Jing,GE Zigang.High-performance Single Compound Multifunctional Agents: Rapid Ligand-Exchange Strategy, Enhanced Dual-modality MR Contrast and Magnetic Hyperthermia[OL]. [ 1 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4522114

In this paper, a rapid ligand-exchange method was developed to transfer high quality hydrophobic magnetite nanocrystals into water-soluble by using protocatechuic acid as ligand via homogenous reaction. After ligand exchange, the magnetite nanocrystals not only exhibited outstanding stability in water, but also maintained high crystallinity and saturation magnetization. Cell viability experiment demonstrated good biocompatibility of the NPs. For 12 nm magnetite nanoparticles (NPs), the small hydrodynamic size of 14 nm enabled high T1 relaxivity of 17.8 mM-1s-1 while high saturation magnetization of 77.8 emu/g make the NPs exhibited high T2 relaxivity of 220 mM-1s-1 in MRI phantom experiment. in vivo MR imaging experiments further confirmed the NPs were eminent T1 and T2 contrast agent. Moreover, the high quality NPs can be used as excellent magnetic heating agents under an alternating magnetic field. With all those features, including dual-mode imaging and magnetic hyperthermia, the NPs can be used as single compound multifunctional agents for various biomedical application, especially for cancer diagnose and treatment.

Keywords:multifunctional agents; magnetic resonance imaging; magnetic hyperthermia; nanoparticle; water-soluble

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