Solid-liquid phase diagram for indomethacin-nicotinamide-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 indomethacin-nicotinamide cocrystal at (298.15 and 313.15) K

SUN Xiaowei; YIN Qiuxiang; XIE Chuang

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

Solid-liquid phase diagram for indomethacin-nicotinamide-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 indomethacin-nicotinamide cocrystal at (298.15 and 313.15) K

SUN Xiaowei,YIN Qiuxiang,XIE Chuang * #

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072

*Correspondence author

#Submitted by

Subject:

Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.SRFDP-20110032120016）

Opened online:26 December 2014

Accepted by: none

Citation: SUN Xiaowei,YIN Qiuxiang,XIE Chuang.Solid-liquid phase diagram for indomethacin-nicotinamide-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 indomethacin-nicotinamide cocrystal at (298.15 and 313.15) K[OL]. [26 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4623875

Solid-liquid equilibrium data for indomethacin (IMC) and nicotinamide (NCT) in both methanol (MeOH) and methanol/ethyl acetate (EA) mixture were measured using static method at (298.15 and 313.15) K under atmospheric pressure. 1:1 IMC-NCT cocrystal and IMCoMeOH was found in both systems under investigated conditions. The solubility of 1:1 IMC-NCT cocrystal was correlated using a mathematical model considering solution complexation. Solubility of IMC-NCT cocrystals as a function of co-former (NCT) concentration was evaluated. It's found that temperature has great effects on the formation of methanol solvate in the investigated systems. Solvate formation could be suppressed either by increasing temperature or using solvent mixtures. Additionally, solvent mixtures could level out the solubility differences between IMC and NCT, resulting in larger and more symmetric region for IMC-NCT cocrystal which would be helpful to the development of the 1:1 IMC-NCT cocrystallization process.

Keywords:phase diagram; solubility; cocrystal; solvate; indomethacin

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded	223
Bookmarked	0
Recommend	5
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers