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| In the previous study,some high expression transgenic igf-1 rice was got and its treatment on diabetic mice had been tested. In order to improve the bioavailability of igf-1 and protect from being decomposed by the digestive enzyme, the rice power had been grinded into power and made into enteric capsule. The best recipe had been tested. Through the enzyme-linked immunosorbent assay (ELISA), the igf-1 content of the rice and the capsule were determined as well as the release rate of the capsule. Type 1 diabetes model and Type 2 diabetes model had been made to inspect the effects that igf-1 capsule has on diabetic mice. The main test contained the weight effect, water intake effect and the glucose effect of igf-1 in different dosage(1mg/g,0.5mg/g and 0.25mg/g). In this study, igf-1 had showed a better effect on mice with T2DM than T1DM,and the treatment effect was closely related with the doasge. |
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| Keywords:igf-1; capsule;treatment; T1DM;T2DM |
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