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| Purpose The effect of complete mesocolic excision on survival is controversial. We did a meta-analysis to compare survival after complete mesocolic excision with non-complete mesocolic excision for patients with colon cancer. Methods We systematically searched Pubmed, ScienceDirect, Cochrane Library, and ClinicalTrials.gov to identify research comparing complete mesocolic excision with non-complete mesocolic excision for patients with colon cancer. The primary endpoint was survival. Results We identified 200 studies, 6 observational studies met selection criteria with a total of 4439 patients (2092 in complete mesocolic excision group, 2347 in non-complete mesocolic excision group). Complete mesocolic excision significantly increased 3-year survival rate and 5-year survival rate compared to non-complete mesocolic excision in patients with colon cancer (HR: 0.73, 95%CI: 0.55 - 0.90, p < 0.0001; HR: 0.40, 95%CI: 0.13 - 0.67, p = 0.034, respectively). For patients with node positive disease, complete mesocolic excision also increased 3-year survival rate (HR: 0.72, 95%CI: 0.52 - 0.92, p < 0.001). Conclusions Complete mesocolic excision was a more effective strategy compared with non-complete mesocolic excision in improving survival of colon cancer. |
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| Keywords:Colon cancer, Survival, Meta-analysis, Complete mesocolic excision |
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