Select Subject

All (8830)

Agronomy (158)

Animal Husbandry,... (64)

Aquatic Science (16)

Astronomy (36)

Aviation (22)

Basic Medicine (184)

Biology (504)

Chemical Engineering (103)

Chemistry (635)

Civil and Archite... (105)

Clinical Medicine (236)

Computer Science ... (924)

Dynamic and Elect... (121)

Earth Science (119)

Economics (67)

Education (31)

Electrics, Commun... (927)

Energy Science an... (67)

Engineering and T... (15)

Environmental Sci... (140)

Food Science and ... (63)

Forestry (36)

Hydraulic Enginee... (40)

Mechanics (240)

Metallurgical Eng... (32)

Mine Engineering ... (38)

Nuclear Science a... (21)

Pharmacy (98)

Physics (920)

Preventive Medici... (37)

Psychology (20)

Security Science ... (17)

Sports Science (6)

Surveying and Map... (15)

Textile Science a... (16)

Traditional Chine... (56)

Transportation En... (57)

Select/Unselect all

For Selected Papers

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list


	1. A FoxO1-Bim pathway is involved in HDAC inhibitor depsipeptide induced apoptosis
	Yang Yang,Ying Zhao,Jing Yang,Wei-guo Zhu
	Basic Medicine 17 March 2009
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are not completely understood. In this study, a novel HDAC inhibitor, depsipeptide was found to induce p53-independent apoptosis in human lung cancer cells. Further study showed that Bim, a BH3-only pro-apoptotic protein, was significantly up-regulated by depsipeptide in cancer cells, indicating Bim may play a role in this depsipeptide induced apoptosis. In additional experiments, Bim’s function in depsipeptide-induced apoptosis was confirmed by knock down of Bim with RNAi. Furthermore, depsipeptide-induced expression of Bim was found to be dependent on forkhead transcription factor 1 (FoxO1) by FoxO1 siRNA. These data show for the first time that HDAC inhibitor may induce apoptosis through the FoxO1-Bim pathway.
	TO cite this article:Yang Yang,Ying Zhao,Jing Yang, et al. A FoxO1-Bim pathway is involved in HDAC inhibitor depsipeptide induced apoptosis[OL].[17 March 2009] http://en.paper.edu.cn/en_releasepaper/content/30413


	2. The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes
	Hui Li,Gang Li
	Basic Medicine 30 December 2008
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Although previous studies have shown that the mechanism of the lymphocyte mu opioid receptor (MOR) gene expression was distinctly different from that in the central nervous system, and is involved in several disparate aspects of the immune response, its precise molecular mechanism is still undefined. In this study, we analyzed the proximal promoter region of the MOR gene in lymphocytes to identify the influences of potential trans-acting factors in activating the initiation of the expression of the MOR gene in lymphocytes. The electrophoretic mobility shift assay showed that two transcription factors, Sp1 and YY1, were able to bind the promoter region. Using sequence overlapping probes and mutation assays, we determined that the CCC sequence of Sp1 and the GGC sequence of YY1 binding elements were core sequences, and replacement of these sequences lead to substantial loss of promoter activity. Stimulation with morphine was capable of up-regulating the intracellular level of Sp1 and YY1 proteins. Chromatin immunoprecipitation assays showed that the blockage of naloxone is achieved through down-regulation of transcription factor YY1. Furthermore, coimmunoprecipitation and transfection assays confirmed that the functional interaction of Sp1 and YY1 transcription factors was a crucial step in the initiation of expression of the MOR in lymphocytes. Thus, we conclude that the cooperative interaction of Sp1 and YY1 transcription factors is the critical event triggering the initiation of transcription of the MOR gene in lymphocytes, and this finding will be helpful to understand the pharmacological effect of morphine on lymphocytes.
	TO cite this article:Hui Li,Gang Li. The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes[OL].[30 December 2008] http://en.paper.edu.cn/en_releasepaper/content/27120


	3. Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes
	Mengsen Li
	Basic Medicine 11 April 2005
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:nvolvement of AFP against apoptosis of tumor cell has been implicated in its evasion of immune surveillance. However, the molecular events of immune escape mechanisms are still unknown. The major observations reported here relate to a possible mechanism by which heptoloma Bel 7402 cells escape immune surveillance in vitro. Western blotting and a well-characterized cofocal scanning image were performed to analyze the expression of Fas/FasL and caspase-3 in co-cultured Bel 7402 and Jurkat cells. After co-culture with Jurkat cells, up-regulated Fas and reduced FasL expression could be observed. Treatment with AFP could remarkably inhibit the elevated Fas and, whereas, induce the FasL expression in co-cultured Bel 7402 cells. Cells co-culture could induce the expression of caspase-3 in both cells line. The elevated caspase-3 in Bel 7402 cells was abolished following the treatment of AFP. The expression of caspase-3 was elevated in co-cultured Jurkat cells treated with AFP. No detectable
	TO cite this article:Mengsen Li. Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes[OL].[11 April 2005] http://en.paper.edu.cn/en_releasepaper/content/1829

Select/Unselect all

For Selected Papers

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Third-level Subject

Rank

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item