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1. Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1 | |||
GENG Shuo,WANG Xiaoyu,XU Xiaoyan,ZHANG Hepeng,MA Yan,ZHANG Yunqi,LI Baoxin,BI Zhenggang,YANG Chenglin | |||
Clinical Medicine 18 December 2013 | |||
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Abstract:In this Increasing evidence suggest that the three homologous members of steroid receptor coactivator (SRC) family (SRC-1, SRC-2 and SRC-3) play key roles in enhancing cell proliferation in various human cancers, such as breast, prostate and hepatocellular carcinoma. However, the function of SRC-3 in osteosarcoma remains largely unexplored. In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues. To explore the functions of SRC-3 in osteosarcoma, in vitro studies were performed in MG63 and U2OS cells. SRC-3 overexpression promoted osteosarcoma cells proliferation whereas knockdown of SRC-3 inhibits its proliferation. In support of these findings, we further demonstrated that SRC-3 up-regulated FoxM1 expression through co-activation of C/EBP. Together, our results show that SRC-3 drives osteosarcoma progression and imply it as a therapeutic target to abrogate osteosarcoma. | |||
TO cite this article:GENG Shuo,WANG Xiaoyu,XU Xiaoyan, et al. Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1[OL].[18 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4571958 |
2. Posterior interosseous nerve entrapment after Monteggia fracture-dislocation in children | |||
Li Hai | |||
Clinical Medicine 22 January 2013 | |||
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Abstract:Object Although most of nerve injuries associated with Monteggia fracture-dislocation in children are neurapraxias and will recover spontaneously after conservative treatment, surgical exploration of the involved nerve is always required in the cases with the entrapment of posterior interosseous nerve (PIN). However, the necessity and time frame for surgical intervention for specific patterns of nerve dysfunction remains controversial. Methods Eight cases, six boys and two girls, with Monteggia fracture-dislocation complicated by PIN injury, managed operatively at the authors' hospital from 2007 to 2008 were retrospectively reviewed. All the patients underwent the attempted closed reduction, before they received exploration of PIN, with open reduction and internal fixation or successful closed reduction. Results The PIN was found to be trapped acutely posterior to the radiocapitellar joint in 4 out of 5 Type III Bado's Monteggia fractures. In the remaining cases, since there were longer time intervals from injury to operation, chronic compressive changes and epineural fibrosis of radial nerve were visualized. After a microsurgical neurolysis performed, the complete recovery in the nerve function was obtained in all the cases during the follow-up.Conclusion The findings from this study suggest that every case of type III Monteggia fracture-dislocation with decreased or absent function of muscles innervated by the PIN and an irreducible radial head in child should be viewed as an indication for immediate surgical exploration of the involved nerve to exclude a potential PIN entrapment. | |||
TO cite this article:Li Hai. Posterior interosseous nerve entrapment after Monteggia fracture-dislocation in children[OL].[22 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4516904 |
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