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1. OAS1 network construction and analysis of the frontal cortex with HIV encephalitis (HIVE) compared with no-encephalitis HIV patients by integrative biocomputation | |||
LI Hao,WANG Lin,HUANG Juxiang | |||
Basic Medicine 14 November 2018 | |||
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Abstract:Single molecular functional network construction and analysis of disease is very useful to identify novel and potential targets for prognosis and therapy. This paper integrated an infer method based on linear programming and decomposition procedure with function analysis using Kappa statistics and fuzzy heuristic cluster (DAVID). We first identified the significant molecule OAS1, then constructed OAS1 up- and down-stream network by infer and further data-mined the main OAS1 modules including response to stimulus, catalytic activity, organelle, metabolic process, alternative splicing and sequence variant from 16 frontal cortex of HIV encephalitis (HIVE) and 12 no-encephalitis HIV patients in the same GEO Dataset GDS1726. Our infer OAS1 network result showed the different gene rate of HIVE as 78% (21/27) compared with the control considering activation and inhibition relationship. The different active genes in HIVE include HLA_B, ISG15_1, ISG15_2, LCAT, LY96, M33210, PDCD4, STAT1, VEZF1, ADH1B, DGKG, IFI35, LSM7, TSPAN4, ZC3HAV1 and the different inhibitory genes include DGKG, CREB5, GAS1, M33210, TENC1, VEZF1. Our integrative analysis showed the positive results of OAS1 response to stimulus, catalytic activity, organelle, metabolic process, alternative splicing and sequence variant through the net numbers of activation minus inhibition compared with the control and predicted the increases of these modules in HIVE. | |||
TO cite this article:LI Hao,WANG Lin,HUANG Juxiang. OAS1 network construction and analysis of the frontal cortex with HIV encephalitis (HIVE) compared with no-encephalitis HIV patients by integrative biocomputation[OL].[14 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746438 |
2. Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits Platelet Function | |||
Gu Yi,Qin Zhenghong | |||
Basic Medicine 07 March 2018
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Show/Hide Abstract | Cite this paper︱Full-text: PDF (813K B) | |||
Abstract:Background-In previous studies, the protection of reduced nicotinamide adenine dinucleotide phosphate (NADPH) on neurons against ischemia/reperfusion-induced injury was determined and its inhibition on platelet aggregation was found by accident. Here, the function of NADPH on platelet is explored deeply. Methods and Results-In vitro studies, the effects of different concentrations of NADPH on platelet aggregation induced by ADP (10 μM), thrombin (0.05 U/mL) or AA (0.5 mM) were determined and we found that NADPH could concentration-dependently inhibit platelet aggregation induced by ADP or thrombin. When the inhibitory effects of NAD+, NADH, NADP+ and NADPH on platelet aggregation were compared, NADPH showed the best effect. In vivo studies, the effects between NADPH and aspirin on tail bleeding time, clotting time and ferric chloride-induced thrombosis model were compared in mice or rats. NADPH could prolong the tail bleeding times in mice, especially at 30 min after the injection of NADPH (7.5 mg/kg), while bleeding times in mice given aspirin (15 mg/kg) were significantly longer at any time point in 6 h. As we detected the influence of NADPH or aspirin on clotting times in rats, we found that both of them had no effect. Using a FeCl3-induced abdominal aorta injury thrombosis model, we found that the injection of NADPH provoked a significant time delay of vessel occlusion, while aspirin almost completely prevented the vessel occlusion. After we observed the injured vessel sections under the microscope, we discovered that the thrombi in injured vessel sections of rats injected NADPH were much looser than rats injected normal saline and the thrombi in injured vessel sections of rats given aspirin were fewest. Conclusions-The current results suggest that NADPH can inhibit platelet aggregation and prevent hemostasis and thrombosis. To our knowledge, this is the first study on the effect of NADPH on platelet function. | |||
TO cite this article:Gu Yi,Qin Zhenghong. Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits Platelet Function[OL].[ 7 March 2018] http://en.paper.edu.cn/en_releasepaper/content/4743750 |
3. Dental Pulp Stem Cells in Tooth Regeneration: Characterizations and Applications | |||
Su Cheng,Zhu Guanyin,Zheng Yi,Gao Bo | |||
Basic Medicine 04 November 2017 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (530K B) | |||
Abstract:In order to make up the deficiency of traditional medical treatment method, regenerative medicine as a new research field has received extensive attention in the recent years. Dental pulp stem cells(DPSCs), originating from the neural crest, become a promising source for tooth regeneration applications for their unique advantages, such as easily isolated and minimally invasive. As a kind of mesenchymal stem cells, DPSCs have the ability to differentiate in several cell phenotypes including odontogenic differentiation, vascularization and neural differentiation. To be applied in tissue engineering, DPSCs are usually combined with various scaffolds and growth factors. Based on the characterizations of DPSCs, they are considered to be a great candidate for application used in regenerative endodontic procedures and whole tooth regeneration. In this review, we have carefully described the important aspects of DPSCs and discussed the practical applications in the present studies. this paper. | |||
TO cite this article:Su Cheng,Zhu Guanyin,Zheng Yi, et al. Dental Pulp Stem Cells in Tooth Regeneration: Characterizations and Applications[OL].[ 4 November 2017] http://en.paper.edu.cn/en_releasepaper/content/4741871 |
4. Characterization of HIV-1 Variants Resistant to an Electronically Constrained Peptide Fusion Inhibitor | |||
Xiyuan Wu | |||
Basic Medicine 04 May 2017 | |||
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Abstract:Emergence of drug resistant HIV-1 mutants is a serious problem for AIDS treatment. SC29EK, a shorter variant of SC34EK, is one of the representative next-generation fusion inhibitors of HIV-1. It shows high activity on inhibiting both wide type and T-20 resistant HIV-1 strains. In this study, we focused on the selection and characterization of HIV-1 escape mutants of SC29EK. Three mutations, Q39R, N43K and E49A located at N-heptad repeat regions and N126K located at C-heptad repeat region of gp41 were identified. High resistance to pocket targeting inhibitor peptides and cross-resistance to enfuvirtide (T20) and sifuvirtide (SFT) were detected, with the mechanisms of significantly reducing binding affinity of the inhibitors and dramatically enhancing interaction of the viral six-helix bundle. Our data helps increase the understanding of the structure-function relationship of gp41 and HIV-1 evolution, providing a reference for the clinical application of fusion inhibitors.????? | |||
TO cite this article:Xiyuan Wu. Characterization of HIV-1 Variants Resistant to an Electronically Constrained Peptide Fusion Inhibitor[OL].[ 4 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4732446 |
5. Development of Fast Scanning Photoacoustic/Ultrasound Microscopy based on Parablic Mirror | |
WU Ning,LI Changhui | |
Basic Medicine 04 May 2017 | |
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