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	1. Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) inhibited TGF beta receptor cognition mechanism
	HONG Tao,WANG Lin
	Basic Medicine 12 June 2022
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) feedback-inhibited beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) and ALG8 downstream-inhibited karyopherin subunit beta 1 (KPNB1) of TGF beta receptor knowledge and molecular subnetworks were constructed from ALG8 feedback-inhibited and downstream-inhibited networks based on integrating microarray significance analysis (SAM), SPSS correlation coefficient Pearson, gene (protein) reconstruction network (GRNInfer) and the Database for Annotation, Visualization and Integrated Discovery (DAVID). ALG8 feedback-inhibited BTRC of TGF beta receptor mechanism was identified upstream inositol 1 4 5-trisphosphate receptor type 1(ITPR1) of BM CD105+Endothelial_3rd, endoplasmic reticulum membrane, fetalbrain_3rd; microtubule associated protein 1B(MAP1B_2) of structural molecule activity; feedback calmodulin binding transcription activator 1(CAMTA1) of ovarian tumor_disease_3rd, ovary_normal_3rd; F-box and leucine-rich repeat protein 5(FBXL5) of protein ubiquitination, ubiquitin protein transferase activity; KIF3A of ATP binding; downstream C1D nuclear receptor corepressor(C1D) of ovarian tumor_disease_3rd, RNA binding; microtubule associated protein 1B(MAP1B_1) of structural molecule activity. ALG8 downstream-inhibited TGF beta receptor mechanism was identified upstream cyclin-dependent kinase 17(PCTK2) of ATP binding; feedback no result; downstream DAZ interacting zinc finger protein 3(DZIP3) of BM CD105+Endothelial_3rd, fetalbrain_3rd, ovarian tumor_disease_3rd, ovary_normal_3rd, ubiquitin protein transferase activity, RNA binding; iron-sulfur cluster assembly 1(ISCA1) of structural molecule activity; SEL1L ERAD E3 ligase adaptor subunit (SEL1L) of endoplasmic reticulum membrane; DDB1 and CUL4 associated factor 7(WDR68) of protein ubiquitination. We put forward ALG8 inhibited TGF beta receptor and cognition mechanism through activation of ATP binding or RE structural molecule or RNA binding or protein ubiquitination effect on fetalbrain, ovarian tumor_disease and normal, BM CD105+Endothelial.
	TO cite this article:HONG Tao,WANG Lin. Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) inhibited TGF beta receptor cognition mechanism[OL].[12 June 2022] http://en.paper.edu.cn/en_releasepaper/content/4757972


	2. Preparation of keratin/chitosan sponge and its application performance evaluation
	YAN Rongrong,SHI Jinsong
	Basic Medicine 13 May 2022
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	Abstract:Uncontrolled bleeding leads to a higher fatality rate in the situation of surgery, traffic accidents and warfare. Traditional hemostatic materials such as bandages are not ideal for uncontrolled or incompressible bleeding. Therefore, it is of great significance to develop a new medical biomaterial with excellent rapid hemostatic effect. As a potential biomedical material, keratin has been developed and paid attention in tissue engineering fields such as promoting wound healing and nerve repair. Herein, a novel keratin/chitosan (K/C) sponge was prepared to achieve rapid hemostasis. The characterizations of K/C sponge were investigated, including SEM, TGA, liquid absorption and porosity, showing that the high porosity up to 90.12 ± 2.17% resulted in an excellent blood absorption. The cytotoxicity test and implantation experiment proved that the K/C sponge was biocompatible and biodegradable. Moreover, the prepared K/C sponge showed better hemostatic performance than chitosan sponge (CS) and the commercially available gelatin sponge in both rat tail amputation and liver trauma bleeding models. Further experiments showed that K/C sponge plays a hemostatic role through the endogenous coagulation pathway, thus shortening the activated partial thromboplastin time (APTT) effectively. Therefore, this study provided a novel K/C sponge which can be served as a promising biomedical hemostatic material.
	TO cite this article:YAN Rongrong,SHI Jinsong. Preparation of keratin/chitosan sponge and its application performance evaluation[OL].[13 May 2022] http://en.paper.edu.cn/en_releasepaper/content/4757746


	3. OAS1 network construction and analysis of the frontal cortex with HIV encephalitis (HIVE) compared with no-encephalitis HIV patients by integrative biocomputation
	LI Hao,WANG Lin,HUANG Juxiang
	Basic Medicine 14 November 2018
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	Abstract:Single molecular functional network construction and analysis of disease is very useful to identify novel and potential targets for prognosis and therapy. This paper integrated an infer method based on linear programming and decomposition procedure with function analysis using Kappa statistics and fuzzy heuristic cluster (DAVID). We first identified the significant molecule OAS1, then constructed OAS1 up- and down-stream network by infer and further data-mined the main OAS1 modules including response to stimulus, catalytic activity, organelle, metabolic process, alternative splicing and sequence variant from 16 frontal cortex of HIV encephalitis (HIVE) and 12 no-encephalitis HIV patients in the same GEO Dataset GDS1726. Our infer OAS1 network result showed the different gene rate of HIVE as 78% (21/27) compared with the control considering activation and inhibition relationship. The different active genes in HIVE include HLA_B, ISG15_1, ISG15_2, LCAT, LY96, M33210, PDCD4, STAT1, VEZF1, ADH1B, DGKG, IFI35, LSM7, TSPAN4, ZC3HAV1 and the different inhibitory genes include DGKG, CREB5, GAS1, M33210, TENC1, VEZF1. Our integrative analysis showed the positive results of OAS1 response to stimulus, catalytic activity, organelle, metabolic process, alternative splicing and sequence variant through the net numbers of activation minus inhibition compared with the control and predicted the increases of these modules in HIVE.
	TO cite this article:LI Hao,WANG Lin,HUANG Juxiang. OAS1 network construction and analysis of the frontal cortex with HIV encephalitis (HIVE) compared with no-encephalitis HIV patients by integrative biocomputation[OL].[14 November 2018] htt

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