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	1. OAS1 network construction and analysis of the frontal cortex with HIV encephalitis (HIVE) compared with no-encephalitis HIV patients by integrative biocomputation
	LI Hao,WANG Lin,HUANG Juxiang
	Basic Medicine 14 November 2018
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (867K B)

	Abstract:Single molecular functional network construction and analysis of disease is very useful to identify novel and potential targets for prognosis and therapy. This paper integrated an infer method based on linear programming and decomposition procedure with function analysis using Kappa statistics and fuzzy heuristic cluster (DAVID). We first identified the significant molecule OAS1, then constructed OAS1 up- and down-stream network by infer and further data-mined the main OAS1 modules including response to stimulus, catalytic activity, organelle, metabolic process, alternative splicing and sequence variant from 16 frontal cortex of HIV encephalitis (HIVE) and 12 no-encephalitis HIV patients in the same GEO Dataset GDS1726. Our infer OAS1 network result showed the different gene rate of HIVE as 78% (21/27) compared with the control considering activation and inhibition relationship. The different active genes in HIVE include HLA_B, ISG15_1, ISG15_2, LCAT, LY96, M33210, PDCD4, STAT1, VEZF1, ADH1B, DGKG, IFI35, LSM7, TSPAN4, ZC3HAV1 and the different inhibitory genes include DGKG, CREB5, GAS1, M33210, TENC1, VEZF1. Our integrative analysis showed the positive results of OAS1 response to stimulus, catalytic activity, organelle, metabolic process, alternative splicing and sequence variant through the net numbers of activation minus inhibition compared with the control and predicted the increases of these modules in HIVE.
	TO cite this article:LI Hao,WANG Lin,HUANG Juxiang. OAS1 network construction and analysis of the frontal cortex with HIV encephalitis (HIVE) compared with no-encephalitis HIV patients by integrative biocomputation[OL].[14 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746438


	2. Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits Platelet Function
	Gu Yi,Qin Zhenghong
	Basic Medicine 07 March 2018
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (813K B)

	Abstract:Background-In previous studies, the protection of reduced nicotinamide adenine dinucleotide phosphate (NADPH) on neurons against ischemia/reperfusion-induced injury was determined and its inhibition on platelet aggregation was found by accident. Here, the function of NADPH on platelet is explored deeply. Methods and Results-In vitro studies, the effects of different concentrations of NADPH on platelet aggregation induced by ADP (10 μM), thrombin (0.05 U/mL) or AA (0.5 mM) were determined and we found that NADPH could concentration-dependently inhibit platelet aggregation induced by ADP or thrombin. When the inhibitory effects of NAD+, NADH, NADP+ and NADPH on platelet aggregation were compared, NADPH showed the best effect. In vivo studies, the effects between NADPH and aspirin on tail bleeding time, clotting time and ferric chloride-induced thrombosis model were compared in mice or rats. NADPH could prolong the tail bleeding times in mice, especially at 30 min after the injection of NADPH (7.5 mg/kg), while bleeding times in mice given aspirin (15 mg/kg) were significantly longer at any time point in 6 h. As we detected the influence of NADPH or aspirin on clotting times in rats, we found that both of them had no effect. Using a FeCl3-induced abdominal aorta injury thrombosis model, we found that the injection of NADPH provoked a significant time delay of vessel occlusion, while aspirin almost completely prevented the vessel occlusion. After we observed the injured vessel sections under the microscope, we discovered that the thrombi in injured vessel sections of rats injected NADPH were much looser than rats injected normal saline and the thrombi in injured vessel sections of rats given aspirin were fewest. Conclusions-The current results suggest that NADPH can inhibit platelet aggregation and prevent hemostasis and thrombosis. To our knowledge, this is the first study on the effect of NADPH on platelet function.
	TO cite this article:Gu Yi,Qin Zhenghong. Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits Platelet Function[OL].[ 7 March 2018] http://en.paper.edu.cn/en_releasepaper/content/4743750


	3. Dental Pulp Stem Cells in Tooth Regeneration: Characterizations and Applications
	Su Cheng,Zhu Guanyin,Zheng Yi,Gao Bo
	Basic Medicine 04 November 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (530K B)

	Abstract:In order to make up the deficiency of traditional medical treatment method, regenerative medicine as a new research field has received extensive attention in the recent years. Dental pulp stem cells(DPSCs), originating from the neural crest, become a promising source for tooth regeneration applications for their unique advantages, such as easily isolated and minimally invasive. As a kind of mesenchymal stem cells, DPSCs have the ability to differentiate in several cell phenotypes including odontogenic differentiation, vascularization and neural differentiation. To be applied in tissue engineering, DPSCs are usually combined with various scaffolds and growth factors. Based on the characterizations of DPSCs, they are considered to be a great candidate for application used in regenerative endodontic procedures and whole tooth regeneration. In this review, we have carefully described the important aspects of DPSCs and discussed the practical applications in the present studies. this paper.
	TO cite this article:Su Cheng,Zhu Guanyin,Zheng Yi, et al. Dental Pulp Stem Cells in Tooth Regeneration: Characterizations and Applications[OL].[ 4 November 2017] http://en.paper.edu.cn/en_releasepaper/content/4741871


	4. Characterization of HIV-1 Variants Resistant to an Electronically Constrained Peptide Fusion Inhibitor
	Xiyuan Wu
	Basic Medicine 04 May 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:Emergence of drug resistant HIV-1 mutants is a serious problem for AIDS treatment. SC29EK, a shorter variant of SC34EK, is one of the representative next-generation fusion inhibitors of HIV-1. It shows high activity on inhibiting both wide type and T-20 resistant HIV-1 strains. In this study, we focused on the selection and characterization of HIV-1 escape mutants of SC29EK. Three mutations, Q39R, N43K and E49A located at N-heptad repeat regions and N126K located at C-heptad repeat region of gp41 were identified. High resistance to pocket targeting inhibitor peptides and cross-resistance to enfuvirtide (T20) and sifuvirtide (SFT) were detected, with the mechanisms of significantly reducing binding affinity of the inhibitors and dramatically enhancing interaction of the viral six-helix bundle. Our data helps increase the understanding of the structure-function relationship of gp41 and HIV-1 evolution, providing a reference for the clinical application of fusion inhibitors.?????
	TO cite this article:Xiyuan Wu. Characterization of HIV-1 Variants Resistant to an Electronically Constrained Peptide Fusion Inhibitor[OL].[ 4 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4732446


	5. Development of Fast Scanning Photoacoustic/Ultrasound Microscopy based on Parablic Mirror
	WU Ning,LI Changhui
	Basic Medicine 04 May 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:We have developed a prototype fast scanning photoacoustic/ultrasound dual-modality microscopy, which provides the complementary information of optics and ultrasound imaging. Based on the design of optical parabolic mirror and water-immersible MEMS scanning mirror, the system achieves fast scanning property as well as confocal effect of collimated light and parallel ultrasound, to acquire a high resolution and simplified configuration. The feasibility of this system is demonstrated by the phantom experiment. The system shows strong potential for the pre-diagnosis of significant diseases.
	TO cite this article:WU Ning,LI Changhui. Development of Fast Scanning Photoacoustic/Ultrasound Microscopy based on Parablic Mirror[OL].[ 4 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4732388


	6. Ginsenoside-Rh2 suppresses proliferation and migration of hepatocellular carcinoma cells by targeting EZH2 to regulate CDKN2A-2B gene cluster transcription
	Li Qi
	Basic Medicine 25 April 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:Ginsenoside-Rh2 (G-Rh2) exerts important pharmacological effects with regard to the control of human hepatocellular carcinoma (HCC). EZH2 is a potent histone methyltransferase of H3K27me3, which has been determined as an oncogene in many malignancies. The CDKN2A-2B gene cluster encodes three important tumor suppressors, P14, P15 and P16. In this study, the anticancer effect and molecular mechanism of G-Rh2 on HCC was investigated. Treatment of HCC cells with G-Rh2 inhibited cell proliferation, migration and induced cell cycle arrest at the G0/G1 phase. We demonstrate for the first time that this effect was specifically mediated by down-regulating expression of EZH2. Further molecular mechanism study indicated that the decreased EZH2 promoted P14, P15 and P16 gene transcription through reducing H3K27me3 modification in the promoter of CDKN2A-2B gene cluster loci. Similarly, silencing of EZH2 by siRNA down-regulated P14, P15, P16 mRNA levels and inhibited HCC cell proliferation. Our results suggested that EZH2 could be a potentially therapeutic target by G-Rh2 in HCC, which provided a rationale for the development of drugs that inhibited histone methylase as a strategy against various cancers.
	TO cite this article:Li Qi. Ginsenoside-Rh2 suppresses proliferation and migration of hepatocellular carcinoma cells by targeting EZH2 to regulate CDKN2A-2B gene cluster transcription[OL].[25 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4727383


	7. The Effects of Colonic Inner Environment on Microbial Fuel Cell Performance
	FU Yuming,Li Hongyan
	Basic Medicine 22 April 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:Microbial fuel cells (MFCs) can produce electricity by utilizing the microorganisms and organic compounds in human large intestine, which might provide a new way for implantable medical devices (IMDs) to have a lasting, stable and safe power source. Our previous work showed that MFC could power IMDs under colonic inner environment of healthy people, but the effects of environmental changes caused by diseases on electricity generation of MFC remain unclear. Therefore, five continuous-flow double-chamber MFCs with simulated colonic content as anodic substrate were constructed and the performance changes under different intestinal peristalsis rates, colonic temperature and pH values were investigated accordingly in this study. The results indicated that most of the environmental changes which may happen during illnesses could lead to the decrease of electricity generation of MFC, except the increase of colonic temperature. However, all of the MFCs could still generate electricity of at least 1.71 mW which could fulfil the requirement of most IMDs. The performance of MFC with multi-factor environmental change simulating diarrhea and fever could maintain stable for about 4h, but with prolonged disease duration, the output voltage dropped dramatically. Generally, MFC has strong potential to be used as power source for IMDs, even under most ill conditions, but strategies should still be applied to improve the stability of output to avoid some extreme conditions.
	TO cite this article:FU Yuming,Li Hongyan. The Effects of Colonic Inner Environment on Microbial Fuel Cell Performance[OL].[22 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4728103


	8. Nuclear translocation of DJ-1 protects the adult neuronal stem cells in MPTP-induced mouse Parkinson's disease model
	SUN Yi,WANG Yupeng,LIN Yuanbin,ZHAO Xin,PU Xiaoping
	Basic Medicine 21 April 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:The DJ-1 gene, originally identified as an oncogene, is a causative gene for a familial form of Parkinson's disease (PD), PARK7. DJ-1 protein was found to play multiple roles in various physiological and pathological processes including cellular transformation, regulating oxidative stress and transcription, as well as cell growth and death. We found previously that DJ-1 was closely associated with the proliferation and differentiation of cultured neuronal stem cells. In this study, we further investigated other functions of DJ-1, in an attempt to determine how adult neurogenesis was affected in the subgranular zones (SGZ), the subventricular zone (SVZ) and olfactory bulb (OB), the brain areas clos

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