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1. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells | |||
Liu Tao,Wang Chun-you,Yu Feng,Gou Shan-miao,Wu He-shui,Xiong Jiong-xin,Zhou Feng | |||
Clinical Medicine 08 April 2009 | |||
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Abstract:AIM: To observe whether PDX-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells in vitro. METHODS: Rat ductal epithelial cells were transfected with recombination plasmids XlHbox8VP16. After transfection, the insulin content of secretion was detected by RIA. The insulin-producing cells were detected by Dithizon-staining. RESULTS: The production and the insulin secretion of insulin-producing cells differentiated from transfected pancreatic ductal epithelial cells were higher than the untransfected in vitro with significant difference (P<0.05). CONCLUSION: PDX-1 can promote rat pancreatic ductal epithelial cells to differentiate into insulin-producing cells obviously in vitro. | |||
TO cite this article:Liu Tao,Wang Chun-you,Yu Feng, et al. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells[OL].[ 8 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31194 |
2. PDX-1 expression and significance in pancreatic cancer | |||
Liu Tao,Gou Shan-miao,Wang Chun-you,Wu He-shui,Xiong Jiong-xin,Zhou Feng | |||
Clinical Medicine 07 April 2009 | |||
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Abstract:AIM: To study the correlations of PDX-1 with pancreatic cancer characteristics. METHODS: RT-PCR and WB were used to detect PDX-1 mRNA expression in pancreatic cancer tissue and normal pancreatic tissue. Immunohistochemistry was also used to detect PCNA. RESULTS: Immunohistochemistry, WB and RT-PCR showed that 41.1% of pancreatic cancers were positive for PDX-1 expression. Lymph node metastasis (P < 0.01), TNM grading (P < 0.05), pathological grading (P < 0.05) and tumor cell proliferation (P < 0.01) were significantly correlated with PDX-1 expression levels. CONCLUSION: PDX-1-positive cells may be tumor stem cells and PDX-1 may act as alternate surface marker of pancreatic cancer stem cells. | |||
TO cite this article:Liu Tao,Gou Shan-miao,Wang Chun-you, et al. PDX-1 expression and significance in pancreatic cancer[OL].[ 7 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31146 |
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