Abstract:Polycyclic aromatic hydrocarbons (PAHs) are a large group of toxic substances produced by the incomplete combustion of organic fuels. They are hydrocarbons with two or more benzene rings and are widely present in environment. Because PAHs cause damage to the respiratory, circulatory, reproductive, immune and cardiovascular systems, they have been the focus of national and international toxicologists. Women are highly susceptible to PAHs and their reproductive functions are extremely vulnerable to PAHs. A large body of reported literature suggests that PAHs exposure can produce uterine reproductive toxicity, such as hormonal disruption, abnormal cell proliferation, altered signaling pathways, regulate genes expression and cancer. PAHs can also cross the placental barrier and affect the zygote in the womb. This review summarizes the toxic effects of various PAHs on the uterus reported in the literature in recent years, and provides an in-depth analysis of the hazards of PAHs exposure on the uterus of the current generation and offspring at the molecular toxicology level.

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	1. Uterine Effects of Exposure to Polycyclic Aromatic Hydrocarbons (PAHs)
	Chen Shen,Hongyu Wang,Miaomiao Zhang,Xuechuan Hong
	Biology 15 March 2024
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	Abstract:Polycyclic aromatic hydrocarbons (PAHs) are a large group of toxic substances produced by the incomplete combustion of organic fuels. They are hydrocarbons with two or more benzene rings and are widely present in environment. Because PAHs cause damage to the respiratory, circulatory, reproductive, immune and cardiovascular systems, they have been the focus of national and international toxicologists. Women are highly susceptible to PAHs and their reproductive functions are extremely vulnerable to PAHs. A large body of reported literature suggests that PAHs exposure can produce uterine reproductive toxicity, such as hormonal disruption, abnormal cell proliferation, altered signaling pathways, regulate genes expression and cancer. PAHs can also cross the placental barrier and affect the zygote in the womb. This review summarizes the toxic effects of various PAHs on the uterus reported in the literature in recent years, and provides an in-depth analysis of the hazards of PAHs exposure on the uterus of the current generation and offspring at the molecular toxicology level.
	TO cite this article:Chen Shen,Hongyu Wang,Miaomiao Zhang, et al. Uterine Effects of Exposure to Polycyclic Aromatic Hydrocarbons (PAHs)[OL].[15 March 2024] http://en.paper.edu.cn/en_releasepaper/content/4762839


	2. Efficient production of ε-poly-L-lysine from L-lysine in <i>Streptomyces albulus</i> by L-lysine importer identification and overexpression
	Zhang Jiawei,Chen Xusheng
	Biology 11 March 2024
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	Abstract:ε-Poly-L-lysine (ε-PL) is a natural cationic antimicrobial peptide widely recognized for its potential in food preservation. Current production methods predominantly rely on de novo synthesis utilizing substrates like glucose, with some studies exploring the supplementation of lysine to enhance fermentation efficiency. However, lysine transporters have not been investigated. In this study, we employed genomic and bioinformatic strategies to pinpoint seven potential lysine transporters in <i>S. albulus</i> . Gene knockout experiments confirmed <i>GL6157</i> as a functional lysine transporter. Overexpression of lysine transporters with different promoters increased lysine consumption by 19.3% and ε-poly-lysine yield by 10% during fermentation
	TO cite this article:Zhang Jiawei,Chen Xusheng. Efficient production of ε-poly-L-lysine from L-lysine in <i>Streptomyces albulus</i> by L-lysine importer identification and overexpression[OL].[11 March 2024] http://en.paper.edu.cn/en_releasepaper/content/4762469

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	3. Preliminary study on the function of 6mA demethylase in Arabidopsis thaliana
	Min Gao,Chongsheng He
	Biology 07 April 2022
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	Abstract:N6-methyladenine (6mA) is the most conservative and common epigenetic marker in prokaryotes. The function and distribution of 6mA in eukaryotes, especially in plants, is still a mystery. It has been reported that 6mA does exist in plants and plays a vital role. However, how 6mA affects plant development, high temperature resistance and stress response is still unknown. 6mA has been proved to be a dynamic modification in eukaryotes, mediated by methyltransferase and demethylase. Arabidopsis thaliana is the model organism for plant biology and system biology research. In this study, we used Arabidopsis thaliana as material to identify 6mA demethylase in plants. Through bioinformatics analysis and in vitro enzyme activity experiment, 6mA demethylase in Arabidopsis thaliana has been found, which paved the road for the study of function and mechanism of demethylase in plants.
	TO cite this article:Min Gao,Chongsheng He. Preliminary study on the function of 6mA demethylase in Arabidopsis thaliana[OL].[ 7 April 2022] http://en.paper.edu.cn/en_releasepaper/content/4757339


	4. Research progress of related methods for controlling targeted protein level
	MIn Gao,ChongSheng He
	Biology 10 August 2021
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	Abstract:In this paper, we reviewed the progress of target protein degradation methods, with special attention to the use of plant hormones to stimulate the degradation. Protein is the key player of many biological processes, interfering the protein level precisely is both important for basic research and clinical application. There are many ways to control the protein level artificially in different levels such as CRISPR-Cas9, RNAi and so on. These methods show different limitations, for example, CRISPR-Cas9 is irreversible, RNAi can cause off-target effect. Targeted protein degradation is one of the ways to regulate the protein level in a post-translational level, it can affect the protein level very fast and reversibly. To achieve targeted protein degradation, different methods have been developed such as small-molecule induced degradation, photo-induced degradation, auxin induced degradation and so on. The core principle is to degrade the target protein in a controllable manner.
	TO cite this article:MIn Gao,ChongSheng He. Research progress of related methods for controlling targeted protein level[OL].[10 August 2021] http://en.paper.edu.cn/en_releasepaper/content/4755399


	5. A 110 nt fragment in the 5\'UTR of STAT2 that determines IRES activity and influences cell proliferation
	Zhou Kantian,Liao Zili,Zhu Ruiyu
	Biology 30 March 2021
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	Abstract:As a unique member of the STAT (Signal Transducer and Activator of Transcription) proteins family, STAT2 cannot recognize DNA target sites as homodimers like the others, yet it plays a critical role in type I interferon (IFN-I) signaling and many other signaling pathways. It was reported that STAT2 could help cells to cope with stress conditions by promoting antiviral responses in normal cells or drug resistance in carcinoma cells. As IRES (Internal Ribosome Entry Sites) were known to help promoting survival of cells under stress, together with the discovery that the 5\'UTR of STAT2 could form stable stem-loop secondary structures with a length of 203 nt, suggesting that there might be IRES activity. To testify this speculation, bicistronic reporter assay was designed as the main method to find out whether the 5\'-UTR of STAT2 harbors an IRES element or not. During the process, the IRES activity was confirmed, followed by the discovery that IRES active central domain was located at nt 33-142 in the 5\'UTR of STAT2. Afterwards, CRISPR/Cas9 techniques were utilized to construct a knockout cell line with the deletion of sequence between nt 65-129 in 5\'UTR. And it was discovered that knockout cells grew slightly faster than those wild type ones, which meant that the knocked-out fragment had an impact on normal cell proliferation. The exact mechanism behind this result remains to be further investigated.
	TO cite this article:Zhou Kantian,Liao Zili,Zhu Ruiyu. A 110 nt fragment in the 5\'UTR of STAT2 that determines IRES activity and influences cell proliferation[OL].[30 March 2021] http://en.paper.edu.cn/en_releasepaper/content/4754243


	6. Enhancement of cytoplasmic solubility of heparinase I from Flavobacterium heparinum in Escherichia coli by adding charged tag and co-expression of molecular chaperonin from hyperthermophilic archaea.
	Guo Yu,Li Huichao,Zhang Hao,Fujiwara Shinsuke,Gao Le
	Biology 01 February 2021
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	Abstract:Heparinase is important in the heparin production and application. The most studied heparinase I is HepA which is secreted by Flavobacterium heparinum. Since HepA was hard to obtain as a soluble form in Escherichia coli, many works were tried to increase cytoplasmic solubility of HepA by adding various protein tags to the HepA terminus. Here we designed a positively charged hexapeptide tag (RGRRGG) which was expected to have enhanced affinity to a chaperonin CpkA from hyperthermophilic archaeaon Thermococcus kodakarensis. HepA was first fused with RGRRGG and expressed by plasmid pET21a. Effect of tag addition on cytoplasmic soluble amount of HepA in E. coli were examined, showing that the amount of the tag fused HepA(HepA\') was boosted in comparison with tag-less original one. HepA\' was next co-expressed with a CpkA by another compatible plasmid pACYCDuet-1. By CpkA co-expression, insoluble amount of HepA\' was decreased and soluble amount of HepA\' was increased and reached to 40% of total expressed amount of HepA\'. The specific activity (126 IU/mg) was also comparable to the native HepA (130 IU/mg). The present data indicated that tag-charged HepA was efficiently obtained as an active form by co-expressing CpkA. (10 Points, Times New Roman)
	TO cite this article:Guo Yu,Li Huichao,Zhang Hao, et al. Enhancement of cytoplasmic solubility of heparinase I from Flavobacterium heparinum in Escherichia coli by adding charged tag and co-expression of molecular chaperonin from hyperthermophilic archaea.[OL].[ 1 February 2021] http://en.paper.edu.cn/en_releasepaper/content/4753657


	7. A 69 nt segment in the 5'UTR regulates translation of FOXO3a under stress conditions
	Zhang Xuyan,Zhou Kantian,Zhu Ruiyu
	Biology 31 March 2020
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	Abstract:Fork head box O3 (FOXO3a) is a transcription factor that mediates various fundamental cellular processes, including cell cycle progression, proliferation, DNA damage and apoptosis. This study showed that the 5\' untranslated region (5\'UTR) of FOXO3a mRNA contains an internal ribosome entry site (IRES). After mapping the 5\'UTR of FOXO3a mRNA, we found that a 69 nt sequence located between 175-243 was the key segment for the overall IRES activity. Further, we generated a knockout cell line of this 69 nt segment using CRISPR technology. During serum-starvation and ADM drug stress, the deletion of this 69 nt segment could inhibit the expression of FOXO3a to some extent in the knockout cells. These results strongly suggested that the 69 nt segment is essential for self-regulation of FOXO3a under stress conditions, and could be a potential target for the regulation of FOXO3a.
	TO cite this article:Zhang Xuyan,Zhou Kantian,Zhu Ruiyu. A 69 nt segment in the 5'UTR regulates translation of FOXO3a under stress conditions[OL].[31 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751435


	8. TH upstream-inhibited DCI subnetwork for learning in human left hemisphere\|Tonsil via nucleo to cytoplasm poly(A) RNA binding
	YANG Kaitong,WANG Lin,HUANG Juxiang
	Biology 24 December 2019
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	Abstract:High tyrosine hydroxylase (TH) upstream-inhibited enoyl-CoA delta isomerase 1 (DCI) molecular subnetwork was constructed, including upstream NCK adaptor protein 2 (NCK2), retinoblastoma binding protein 6 (RBBP6), sulfotransferase family 1A member 2 (SULT1A2); downstream chromosome 10 open reading frame 10 (C10orf10), forkhead box N3 (FOXN3_2), poly (rC) binding protein 2 (PCBP2_2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited DCI subnetwork was identified by DAVID, containing upstream NCK2, upstream RBBP6, upstream SULT1A2, downstream FOXN3_2, downstream PCBP2_2, first-core TH as protein binding; upstream SULT1A2, second-core DCI, first-core TH as small molecule metabolic process; upstream RBBP6, downstream PCBP2_2 as poly(A) RNA binding; downstream PCBP2_2, first-core TH as enzyme binding; The common cellular component of upstream NCK2, upstream RBBP6, downstream PCBP2_2, first-core TH as cytoplasm; upstream NCK2, upstream SULT1A2, downstream PCBP2_2, first-core TH as cytosol; downstream C10orf10, second-core DCI, first-core TH as mitochondrion; downstream FOXN3_2, downstream PCBP2_2, first-core TH as nucleus; upstream RBBP6, downstream PCBP2_2 as nucleoplasm; downstream PCBP2_2, second-core DCI as extracellular exosome; The common tissue distributions as Tonsil_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited enoyl-CoA delta isomerase 1 (DCI) subnetwork for learning in human left hemisphere\|Tonsil via nucleo to cytoplasm poly(A) RNA binding.
	TO cite this article:YANG Kaitong,WANG Lin,HUANG Juxiang. TH upstream-inhibited DCI subnetwork for learning in human left hemisphere\|Tonsil via nucleo to cytoplasm poly(A) RNA binding[OL].[24 December 2019] http://en.paper.edu.cn/en_releasepaper/content/4750327


	9. TH upstream-inhibited CYFIP2 subnetwork for learning via cytoplasm to nucleus small GTPase mediated signal transduction
	ZHANG Weijian,HUANG Juxiang,WANG Lin
	Biology 23 December 2019
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	Abstract:High tyrosine hydroxylase (TH) upstream-inhibited cytoplasmic FMR1 interacting protein 2 (CYFIP2) molecular subnetwork was constructed, including feedback SMAD family member 1 (SMAD1_2); downstream Rho GTPase activating protein 12 (ARHGAP12), forkhead box N3 (FOXN3_2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited CYFIP2 subnetwork was identified by DAVID, containing feedback SMAD1_2, downstream FOXN3_2, second-core CYFIP2, first-core TH as protein binding; feedback SMAD1_2, downstream FOXN3_2 as transcription factor activity sequence specific DNA binding; downstream ARHGAP12, second-core CYFIP2 as small GTPase mediated signal transduction; The common cellular component of feedback SMAD1_2, downstream FOXN3_2, second-core CYFIP2, first-core TH as nucleus; feedback SMAD1_2, downstream ARHGAP12, second-core CYFIP2, first-core TH as cytosol; feedback SMAD1_2, second-core CYFIP2, first-core TH as cytoplasm; second-core CYFIP2, first-core TH as neuron projection; The common tissue distributions as ADIPOCYTE_3rd, CD8+T cells_3rd, PLACENTA_3rd, salivarygland_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited cytoplasmic FMR1 interacting protein 2 (CYFIP2) subnetwork for learning in human left hemisphere\|ADIPOCYTE\|CD8+T cells\|PLACENTA\|salivarygland via cytoplasm to nucleus small GTPase mediated signal transduction.
	TO cite this article:ZHANG Weijian,HUANG Juxiang,WANG Lin. TH upstream-inhibited CYFIP2 subnetwork for learning via cytoplasm to nucleus small GTPase mediated signal transduction[OL].[23 December 2019] http://en.paper.edu.cn/en_releasepaper/content/4750249


	10. Comparing gene co-expression networks and modules across 52 tissues
	Tian Yingxiang,海南师范大学，数学与统计学院，海口，570100,Liao Bo
	Biology 05 May 2019
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	Abstract:The genotype-tissue expression project collects and analyzes a variety of human tissues from donors of the same dense genotype. The Weighted Gene Co-Expression Network (WGCNA) method can construct networks based on the similarity of gene expression data between the two genes to discover inter-gene relationships. This study aims to discover inter-organizational relationships by building the networks of tissues based on weighted gene co-expression network methods and the tissue gene expression profiles provided by GETX. In the experiment, the network was constructed for each tissue, and the hypothesis test was used to analyze the intern-organizational correlation. Combined with some gene ontology function enrichment analysis, the common functional characteristics among all the tissues and some immune function enrichment situation was found. After that, correlation analysis is performed on the modules generated by the tissue network, the maximum group analysis of the module network is performed, and the modules which highly enriched immune functions are analyzed.
	TO cite this article:Tian Yingxiang,海南师范大学，数学与统计学院，海口，570100,Liao Bo. Comparing gene co-expression networks and modules across 52 tissues[OL].[ 5 May 2019] http://en.paper.edu.cn/en_releasepaper/content/4748667

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