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1. DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human | |||
LIU Xiaoxiao,HUANG Juxiang,WANG Lin | |||
Biology 07 November 2018 | |||
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Abstract:DDX3Y computational catalytic network construction and analysis of human left brain is very useful to identify novel markers and potential targets for the understanding of brain mechanism. By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID 2010 version) we identified and constructed significant molecule DDX3Y catalytic network from 15 chimpanzee and 14 human left brain samples in the same GEO Dataset GDS2678. Our result verified DDX3Y catalytic module only in the downstream of chimpanzee left brain (AGL, PDIA2, PPID, RBBP6 activation; ENOSF1, GSTM3, RECQL, RPP14 inhibition) and downstream (DDX19A, ENPP2, RPP14, SPTLC1activation; AGL, ENOSF1, GSTM3, RECQL, HERC2P2, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RBBP6 inhibition), whereas in the upstream of human left brain (GSTM3, HSD17B6, PCSK6 activation; EGFR, ENOSF1 inhibition) and downstream (AGL, DDX19A, EGFR, HSD17B6 activation; ABCC10, ENPP2, GSTM3, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RECQL, SPTLC1 inhibition). Importantly, we datamined that DDX3Y catalytic cluster of human left brain is involved in nervous system development, ubl conjugation, response to chemical stimulus, neurogenesis, cell development and cognition, regulation of apoptosis, anatomical structure development, ATPase activity, coupled, endoplasmic reticulum, polysaccharide binding, pyrophosphatase activity, cellular localization, transport and calcium ion binding (only in human left brain terms) without Isomerase and zinc ion binding (only in chimpanzee left brain terms), the condition is vital to central nervous system development and cognition of human left brain. Our result demonstrated that common terms in both chimpanzee and human left brain include phosphoprotein, hydrolase, organelle, metabolic process, nucleic acid binding, metal-binding, acetylation, DNA binding, Golgi apparatus, identical protein binding, homeostatic process, signal transducer activity, membrane, developmental process, glycoprotein, cytoskeletal protein binding, regulation of cellular process and biosynthetic process, and these terms are more relative to development and cognition, therefore we deduced the stronger DDX3Y catalytic network in human left brain consistent with our number computation. It would be necessary of the stronger DDX3Y catalytic function to development and cognition of human left brain. | |||
TO cite this article:LIU Xiaoxiao,HUANG Juxiang,WANG Lin. DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human[OL].[ 7 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746419 |
2. A Filament-Assembling-Pressure Model for Developing Forces by Actin Polymerizing | |||
Wang Xiaoen | |||
Biology 13 February 2009 | |||
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Abstract:The investigations of mechanisms for developing forces by actin polymerization come mainly from two models so far, sliding filament and Brownian ratchet models. Both models were difficult to clarify many experiment phenomena, and made some confusion at theory. Such mechanism is still not full understood because of difficulty in experiment observations at molecular level. Based on nucleation mechanisms of crystal, Young’s pressure, and ability of filaments to transmit water, this paper proposes a filament-assembling-pressure model by which can explain almost all of interrelated experiment phenomena. Assembly of a filament at its one end will produce redundant water because of monomer disappearance in the small microcosmic circumscription about polymerization site. The redundant water will diffuse to other end along the filament, and result in a pressure of water flow, filament-assembling pressure, by which propels loads, transfers signal or nutriments, and transforms chemical energy of polymerization into forces. | |||
TO cite this article:Wang Xiaoen. A Filament-Assembling-Pressure Model for Developing Forces by Actin Polymerizing[OL].[13 February 2009] http://en.paper.edu.cn/en_releasepaper/content/28983 |
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