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1. Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10 | |||
Cui-Xiang Xu,Zhan-Kui Jin,Pu-Xun Tian | |||
Clinical Medicine 09 May 2018 | |||
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Abstract:Background/Aims: Biomarkers are urgently required for predicting rejection and for early anti-rejection treatment to prevent the functional impairment of the graft. We hypothesized that the combination of circulating fractalkine, IFN-γ and IP-10 might serve as effective biomarkers for predicting early acute rejection. Methods: We conducted a retrospective study of 87 subjects, who were classified into acute rejection group (ARG; n=38) and non-rejection group (NRG; n=49). Serum fractalkine, IFN-γ and IP-10 levels were measured by Luminex. Results: The levels of fractalkine on day 0, IP-10 on 4th day, fractalkine, IFN-γ and IP-10 on the 7th day in ARG was significantly higher than that in NRG. Kaplan-Meier survival analysis highlighted the higher-levels of fractalkine on day 0, 4th and 7th day, IFN-γ on day 0, 1st, 4th, and 7th day and IP-10 on the 4th and 7th day in rejection-free survival probability were significantly lower than low-levels. ROC analyses highlight the superiority of fractalkine on day 0, IP-10 on day 0, 4th and 7th day, and IFN-γ on day 0, 1st and 7th day in prediction of acute rejection. We found the combination of fractalkine on day 0, IP-10 on 7th day and IFN-γ on 7th day had the highest AUC (0.866) for predicting rejection with a sensitivity of 86.8% and a specificity of 89.8%. Conclusion: Our findings demonstrated a more powerful prediction of early acute renal allograft rejection by combination of multiple-biomarkers of fractalkine, IFN-γ and IP-10, and the results might help stratify the immunologic risk of acute allograft rejection in patients.????? | |||
TO cite this article:Cui-Xiang Xu,Zhan-Kui Jin,Pu-Xun Tian. Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10[OL].[ 9 May 2018] http://en.paper.edu.cn/en_releasepaper/content/4745000 |
2. Can EC-MPS reduce gastrointestinal side effects in de novo renal transplant recipients? | |||
LI Fei,WANG Dongping,ZHAO Qiang,PAUL M.Schroder,LU Yao,ZHENG Zhouying,GUO Zhiyong,HE Xiaoshun | |||
Clinical Medicine 23 November 2015 | |||
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Abstract:Mycophenolate mofetil (MMF) is one of the major immunosuppressants commonly used in transplant recipients. Enteric coated mycophenolate sodium (EC-MPS) is expected to have immunosuppressant effects equivalent to MMF while reducing gastrointestinal adverse events. Here we conducted a meta-analysis on the comparison of outcomes of de novo renal transplant recipients using MMF versus EC-MPS. There was no statistical significance between EC-MPS and MMF groups in the incidence of gastrointestinal adverse events at both 3 months (Z=0.40, P=0.69) and 12 months (Z=0.45, P=0.65)after grouping. No difference was found in the incidence of dose reduction or interruption due to gastrointestinal adverse events between the two groups (Z=1.46, P=0.14 and Z=1.37, P=0.17). Similarly, no statistical significance was documented in the comparison of drug discontinuation due to gastrointestinal adverse events between the two groups at 12 months after grouping (Z=0.44, P=0.66). The 12-month biopsy proven acute rejection rates were comparable (Z=1.21, P=0.22). In summary, the current evidence suggests that EC-MPS has similar efficacy to MMF as an immunosuppressant but does not reduce the incidence of gastrointestinal side effects. | |||
TO cite this article:LI Fei,WANG Dongping,ZHAO Qiang, et al. Can EC-MPS reduce gastrointestinal side effects in de novo renal transplant recipients?[OL].[23 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4664319 |
3. Value and long-term effect of salvage liver transplantation met Hangzhou criteria. :a report of 51 cases | |||
ZHANG Tong,FU Binsheng,LI Hua,XU Chi,YI Shuhong,Wang Genshu,ZHANG Jian,JIANG Nan,YANG Yang,CHEN Guihua | |||
Clinical Medicine 24 December 2013 | |||
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Abstract:Objective To evaluate clinical application and the long-term effect of salvage liver transplantation(SLT)met Hangzhou criteria. Methods The clinical data of 71 patients who underwent SLT by cadaveric grafts treating for hepatocellular carcinoma met Hangzhou criteria from October 2003 to July 2012 were analyzed retrospectively. Among them, 51 patients (intrahepatic recurrence 46;hepatic failure 5) underwent SLT met the Hangzhou criteria, and 40 patients(intrahepatic recurrence 36;hepatic failure 4) met the Milan criteria . Perioperative factors and survival were compared between two groups. Results All patients were followed up. The follow-up time was from 0 to 101 months (median 38.7 months). During follow-up time,there were 12 patients(24%)with tumor recurrence. Though the chance of tumor recurrence increases 8.3%,the number of recipient increases 27.5% by the use of Hangzhou criteria. There was no statistical difference in terms of anhepatic phase, overall ischaemic time, operative time, blood loss, packed red blood cell transfusion, fresh frozen plasma transfused, complication of transplanted liver, retransplantation rate, perioperative mortality(30-day)rate , perioperative mortality(30-day)rate , tumors recurrence rate between SLT groups met Milan criteria and SLT group met Hangzhou criteria (P>0.05). 1-year,3-year,5-year overall and disease-free survivals were not significantly different (100%、86%、73% versus 98%、82%、72%,χ2=0.05,P=0.82; 97.2%、77.1%、74.1% versus 96%、75%、72%,χ2=0.08,P=0.78, respectively) between the SLT group met Milan criteria and SLT group met Hangzhou criteria . Conclusions Milan criteria is the most appropriate indications for SLT. Hangzhou criteria increases the number of recipient, but it did not significantly increase the chance of tumor recurrence. | |||
TO cite this article:ZHANG Tong,FU Binsheng,LI Hua, et al. Value and long-term effect of salvage liver transplantation met Hangzhou criteria. :a report of 51 cases[OL].[24 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4576908 |
4. Recipient bone marrow-derived cells contribute to neointimal formation after aortic transplantation in rat | |||
Song Zifang,Zheng Qichang,Liu Shanglong,Hu Shaobo,Li Jun,Xiong Jun,Shang Dan,Zhang Yong,Hu Qinggang | |||
Clinical Medicine 23 February 2011 | |||
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Abstract:Objective: To examine the expression of Sry gene in neointimal smooth muscle cells, detect its origin in rat aortic allograft following transplantation. Methods:Sex-mismatched bone marrow transplantation was performed from male Wistar rats to female Wistar rats, and the chimeric rat were prepared. Four weeks later, the rat aortic transplantation model was constituted by means of micro-surgery. The recipients were divided into four groups: male-male aortic isograft group, male-male aortic allograft group, female-chimera aortic allograft group and female-female aortic allograft group. Eight weeks after transplantation, aortic grafts were removed and processed. Histopathological examination and immunohistochemical staining was carried out in aortic sections. α-SMA-positive neointimal cells were harvested from cryostat sections of aortic allograft by microdissection method, and the Sry gene was amplified from the cell DNA by PCR. Results:In all aortic allografts, but not aortic isografts, α-SMA-positive smooth muscle cells were proliferated and accumulated excessively, which resulted in significant neointimal formation and vascular lumen narrowing in aortic grafts. Neointima quantitative assay revealed that the neointimal area and neointimal area/medial area ratio of grafted aorta were significantly higher in all of aortic allograft groups than that of the aortic isograft group (P<0.01), and there was no significant difference between aortic allograft groups (P>0.05). PCR amplification assay indicated that the expression of Sry gene was positive in neointimal smooth muscle cells of aortic allografts in female-chimera and male-male aortic allograft groups respectively, but not in the female-female aortic allograft group. Conclusions:As a source of neointimal smooth muscle cells, recipient bone marrow derived-cells participate in the pathological neointimal hyperplasia and allograft arteriosclerosis in rat. Recipient bone marrow-derived cells may be interesting therapeutic targets for chronic allograft vasculopathy. | |||
TO cite this article:Song Zifang,Zheng Qichang,Liu Shanglong, et al. Recipient bone marrow-derived cells contribute to neointimal formation after aortic transplantation in rat[OL].[23 February 2011] http://en.paper.edu.cn/en_releasepaper/content/4411867 |
5. Treatment of HBV and HCV seropositive patients after renal transplantation | |||
liuhua,Xue Wujun,Tian Puxun,Ding Xiaoming,Feng Xinshun | |||
Clinical Medicine 10 February 2009 | |||
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Abstract:Backgroud/Purpose. There are higher incidence of hepatitis virus infection in renal transplant patients. In present study, we evaluated the risk and investigate the effect of integrative treatment on renal transplant patients with hepatitis B surface antigen (HBsAg) and/or seropositivity for anti-hepatitis C virus (HCV) antibody. Methods. A total of 79 HBsAg-positive and/or anti-HCV-positive patients underwent transplantation (78 kidney, one kidney and liver) between 2000 and 2007. After renal transplantation, patients with liver dysfunction received integrative therapy, including adjustment of dosage and/or type of immunosuppressants, and hepatic protection depending on the extent of the liver dysfunction. Hepatitis B virus (HBV)-DNA-positive patients were treated with lamivudine to inhibit viral replication. Results. On review of the total programme, 40 patients (50.63%) experienced liver dysfunction in the first 2 months post-operation, and five (6.33%) of these patients were HBV-DNA or HCV-RNA positive. The liver dysfunction rate was 26.09% in patients treated with tacrolimus/ mycophenolate mofetil (MMF)/prednisone (Pred), and was 60.71% in those treated with cyclosporine/MMF/Pred (P<0.05). After integrative therapy, the liver function of 36 (90%) patients was restored to normal. At the last follow-up, the survival rate of the patients and grafts was 98.48/98.48%, 92.31/92.31% and 89.26/85.71% at 1, 3 and 5 years, respective1y. Conclusion. These data suggest that timely hepatic protection and anti-viral treatment and appropriate adjustment of immunosuppressant dosage and/or type may improve the survival rate of renal transplant patients who are positive for hepatitis virus. | |||
TO cite this article:liuhua,Xue Wujun,Tian Puxun, et al. Treatment of HBV and HCV seropositive patients after renal transplantation[OL].[10 February 2009] http://en.paper.edu.cn/en_releasepaper/content/28744 |
6. Evaluation of Emergency Endobronchial Stents Placement in Serious Main Bronchial Stenosis Following High-risk Orthotopic Heart Allotransplantation | |||
Zhao Yongxiang,Zhao Lingling,Yi Bo,Shan Zhonggui,Fan Qinming,Ke Mingyao,Liao Chongxian,Ye Qifa,Huang Zufa,Zhu Yue | |||
Clinical Medicine 26 May 2006 | |||
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Abstract:Objective: To investigate the curative effect of emergency stent placement for left main bronchial malacia, stenosis and collapse after orthotopic heart allotransplantation. Methods: To evaluate the risk and efficacy of treatment of bronchus stent placement after orthotopic heart allotransplantation in one dilated cardiomyopathy patient complicated with left main bronchial malacia, stenosis and collapse resulting in left pulmonary ventilation dysfunction, and other multi-diseases, such as severe pulmonary artery hypertension and mixed(mainly central) sleep apnea syndrome. Results: After treatment of stent placement, patient was relieved from left pulmonary ventilation dysfunction with obviously improved hypercapnia, hypoxemia, pulmonary hypertension and the function of transplanting heart recovered. Conclusions: Emergency treatment with stent placement for bronchial malacia, stenosis and collapse occurring after orthotopic heart allotransplantation could improve ventilation dysfunction caused by bronchial malacia and stenosis, and increase the survival rate of heart transplantation. | |||
TO cite this article:Zhao Yongxiang,Zhao Lingling,Yi Bo, et al. Evaluation of Emergency Endobronchial Stents Placement in Serious Main Bronchial Stenosis Following High-risk Orthotopic Heart Allotransplantation[OL].[26 May 2006] http://en.paper.edu.cn/en_releasepaper/content/6814 |
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