Authentication email has already been sent, please check your email box: and activate it as soon as possible.
You can login to My Profile and manage your email alerts.
If you haven’t received the email, please:
|
|
There are 37 papers published in subject: since this site started. |
Select Subject |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
1. The circadian clock system in lung cancer | |||
Hou Xinzhu,Tao Shasha | |||
Preventive Medicine and Hygienics 12 May 2021 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Lung cancer is the leading cause of cancer deaths worldwide. Despite the extensive characterization of events, which contribute to tumor initiation and progression, more and more recent studies forces on the relationship between circadian rhythm, like shift work and jet lag, and lung tumorigenesis. It is clear that the circadian clock system in lung is not only controlled by SCN, but also isolated from the SCN in some ways. There exists a negative and positive transcription/translation-based feedback loops in lung. Therefore, that the disorder of circadian clock system can lead to the risks of lung cancer has been described in multiple ways, including genes, cells, metabolism, immune function and inflammation processes and so on. This review emphasizes the important role of the circadian clock system in lung cancer, integrates the multiple relationship between circadian clock system and lung tumorigenesis, and hence puts forward new prospects in the prevention and cure of lung cancer. | |||
TO cite this article:Hou Xinzhu,Tao Shasha. The circadian clock system in lung cancer[OL].[12 May 2021] http://en.paper.edu.cn/en_releasepaper/content/4755035 |
2. Accurate Simulations and Analysis of Xinfadi COVID-19 Epidemics in Beijing | |||
Min Lequan | |||
Preventive Medicine and Hygienics 19 December 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract: To date, more than 71 millions on infected with COVID-19 have been identified worldwide. It causes more 1.6 millions deaths and affects more than 200 countries and regions. Establishing a mathematical model for epidemic infectious diseases has played an important role in the formulation, evaluation, and prevention of control strategies. The event of Xinfadi COVID-19 epidemic provides a successful example for prevent and control strategies and clinical treatments. This paper introduces a symptomatic-asymptomatic-recoverer differential equation model (SARDE). It gives the conditions of the stability on the disease-free equilibrium of SARDE. It proposes the necessary conditions of disease spreading. It determines the parameters of SARDE based on the reported data of Xinfadi COVID-19 epidemic and simulations. Numerical simulations of SARDE describe well the outcomes of current symptomatic individuals, current asymptomatic but infected individuals, recovered symptomatic infected individuals, and recovered asymptomatic but infected individuals. The numerical simulations suggest that both symptomatic and asymptomatic individuals cause lesser asymptomatic spread than symptomatic spread; blocking rate of 97% cannot prevent the spread of Xinfadi COVID19 epidemic; the strict prevention and control strategies implemented by Beijing government are not only very effective but also completely necessary. It is expected that the research results can provide new theoretical tools and ideas worthy of reference for better understanding and dominating of epidemic spreads, preventions and controls. | |||
TO cite this article:Min Lequan. Accurate Simulations and Analysis of Xinfadi COVID-19 Epidemics in Beijing[OL].[19 December 2020] http://en.paper.edu.cn/en_releasepaper/content/4753222 |
3. Simulations and Estimations of COVID-19 Epidemics in Beijing and Shanghai | |||
Min Lequan | |||
Preventive Medicine and Hygienics 27 July 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:The 2019 novel coronavirus (COVID-19) is a new virus that causes respiratory illness in people. This virus was first identified during an investigation into an outbreak in December 2019 Wuhan, China. To date, more than 15 millions on infected with COVID-19 have been identified worldwide. It causes more 600,000 deaths and affects more than 200 countries and regions. Establishing a mathematical model for epidemic infectious diseases has played an important role in the formulation,evaluation,and prevention of control strategies.This paper introduces such a model (INSIAR). This model improves one our previous mathematical model: susceptible-infected- asymptomatic-recoverer (NSIAR), and provides a subsidiary model (SM). SM can decribe the evolotions of cuumulative died, recovered infected and recovered asymptomatic individuals. Consequently INSIAR can provide more clear and detailed interpretations to the dynamics of COVID-19 epidemic than those done by NSIAR. The solutions of INSIAR are all positive and bounded. NSIAR has a disease-free equilibrium and a disease-persistent equilibrium. It provides criterions of local stability, and conditions of globally asymptotical stability on the disease-free equilibrium. It gives criterions of epidemic spread. As applications, utilizing the reported data of COVID-19 epidemics in Beijing and Shanghai (form the first infections discoveries to about two weeks\' after infectious peak points) , this paper determines the model parameters with different periods, simualtes and estimates the outmomes of the COVID-19 epidemics in Beijing and Shanghai, and evaluate the prevention of control strategies in Beijing and Shanghai. Simulation results are close to some repoted clinic data of the COVID-19 in Beijing and Shanghail. If Beijing would take group imunity or loose imunity measures for COVID-19 epidemics. Simulation results showed that in both cases, there were about 230000 death cases, and the end date of the loose imunity was not earlier than that of the group imunity. However, If the authority and people in Beijing keep the current strict prevention and control measures, a few outside input COVID-19 infectious cases will not generate epidemic spreading. The analysis suggest that Beijing and Shanghai have similar infecting and spreading patterns of COVID-19 epidemics. Both cites have implemented almost the same prevent and control measures. It is expected that the research results can provide new theoretical tools and ideas worthy of reference for better understanding and dominating of epidemic spreads, preventions and controls. | |||
TO cite this article:Min Lequan. Simulations and Estimations of COVID-19 Epidemics in Beijing and Shanghai[OL].[27 July 2020] http://en.paper.edu.cn/en_releasepaper/content/4752590 |
4. Platelet parameters were associated with osteoporosis in large Chinese populations | |||
SUN Li-Li,LEI Shu-Feng | |||
Preventive Medicine and Hygienics 16 March 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Purpose Hematological changes related to osteoporosis in elder people are largely unknown. Our aim is to systemically evaluate associations between platelet parameters and osteoporosis in two large Chinese elder populations. Materials and Methods Subjects were selected from our ongoing cohort study: Osteoporosis Preventive Project (OPP), they were 982 from Shishan Community Health Center (Sample 1) and 3675 from Loujiang Community Health Center (Sample 2).The two hospitals used different models of instruments to detect platelet parameters, namely, Mindray BC-5800 automatic five-class blood cell analyzer and Mindray BC-2600 automatic three-class blood cell analyzer. Platelet parameters include platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT). BMD (g/cm2) was measured by dual-energy X-ray absorptiometry with Hologic densitometers (Hologic Inc., USA). We performed the Kruskal-Wallis rank test, Spearman correlation analysis and partial correlation analysis to detect the associations between the platelet parameters and BMD. Results Since most of basic characteristics of the two samples differed significantly (P<0.001), we separately analyzed the two samples. Among three groups categorized by LS BMD, PLT, PDW, and PCT were significantly different among the three groups. These results were consistent and replicated in the two samples (P<0.05). Similarly, significant differences only for PLT (P=0.003) and PCT (P=0.004) were observed in the Sample 2 among three groups categorized by FN BMD. The PLT and PCT were negatively correlated with LS BMD and FN BMD (P<0.01) in both samples when unadjusted, but after adjustment with sex, age and BMI, only two correlations were still significant (PLT and FN BMD, PCT and FN BMD in the Sample 2). Contrary to PLT and PCT, PDW was positively associated with LS BMD and FN BMD when unadjusted in both samples (P<0.01). However, the significantly positive correlations were only observed in the Sample 2 after adjustment. Conclusion The results suggest that three parameters (PLT, PDW and PCT) have significant correlations with BMD, but MPV has no associations with BMD. | |||
TO cite this article:SUN Li-Li,LEI Shu-Feng. Platelet parameters were associated with osteoporosis in large Chinese populations[OL].[16 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751215 |
5. 1α,25(OH)2D3 regulates the expression profile of lncRNAs in the ovarian cancer cell line SKOV-3 | |||
XUE Yaqi,YE Mengxuan,WANG Songzhi,PEI Hailong,HU Wentao,JIANG Fei,ZHOU Guangming,LI Bingyan | |||
Preventive Medicine and Hygienics 10 February 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Long non-coding RNAs (lncRNAs) have been reported to be involved in processes of tumor progression. 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), the active form of vitamin D, has an anti-proliferative effect on tumor cells. Therefore, differentially expressed lncRNAs regulated by 1α,25(OH)2D3 may be associated with tumor progress. This study was aimed to investigate the lncRNAs profiling pattern regulated by 1α,25(OH)2D3 in ovarian cancer cell line SKOV-3 using microarray analysis. After 72 hours of 1α,25(OH)2D3 treatment, 139 lncRNAs and 105 mRNAs were significantly dysregulated. Five lncRNAs were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). In functional analysis, dysregulated lncRNAs can participate in biological processes related to systemic lupus erythematosus, alcoholism, osteoclast differentiation and cancer signaling pathways, such as Wnt, TNF and TGF-β receptor signaling. The dysregulated lncRNAs were associated with their co-expressed genes and may be mainly regulated by these three transcription factors, TAF7, POU2F2 and KAT2A. Additionally, there were 17 lncRNAs co-expressed with genes VDR, CYP24A1 and CDH1, suggesting that these lncRNAs acted as the connection to associate vitamin D signaling with EMT. These data constitute the first report of lncRNA expression patterns regulated by 1α,25(OH)2D3 in human ovarian cancer cells, and will provide new evidence for the anti-tumor effect of 1α,25(OH)2D3 through lncRNAs. | |||
TO cite this article:XUE Yaqi,YE Mengxuan,WANG Songzhi, et al. 1α,25(OH)2D3 regulates the expression profile of lncRNAs in the ovarian cancer cell line SKOV-3[OL].[10 February 2020] http://en.paper.edu.cn/en_releasepaper/content/4750682 |
6. Knockdown of CYP24A1 enhances the anti-invasion effect of 1α,25(OH)2D3 on mouse ovarian cancer cells by inhibiting EMT | |||
Xu Jiming,Wang Ping,Hou Yongfeng,Jiang Fei,Li Bingyan | |||
Preventive Medicine and Hygienics 27 March 2019 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Increasing evidence has shown that epithelial-mesenchymal transition (EMT) can endow cancer cells with motile and invasive properties. In ovarian tissue, EMT not only plays a physiological role in the postovulatory repair of ovary surface epithelial (OSE) cells, but also an important role in the aggressiveness and recurrence of ovarian cancer. Previous research has indicated that 1α,25(OH)2D3 decreases the migration and invasion of many kinds of tumor cells by suppressing EMT. However, it remains unclear whether 1α,25(OH)2D3 can inhibit the process of EMT in mouse OSE (MOSE) cells at different stages of oncogenic transformation. In this study, we found that 1α,25(OH)2D3 significantly reduced the migration and invasion of late malignant transformed MOSE (M-L cells) cells by inhibiting EMT both in vitro and in vivo, but not in intermediate transformed (M-I) cells. Interestingly, the expression of CYP24A1 in M-I cells was distinctly higher than M-L cells following continuous treatment with 1α,25(OH)2D3. Furthermore, we demonstrated that the knockdown of CYP24A1 enhanced the anti-invasion properties of 1α,25(OH)2D3 on both M-I and M-L cells by upregulating the expression of E-cadherin, and downregulating the expression of N-cadherin, Vimentin, β-catenin and Snail. These findings imply that CYP24A1 is a potential target for the inhibition of EMT and ovarian cancer metastasis. | |||
TO cite this article:Xu Jiming,Wang Ping,Hou Yongfeng, et al. Knockdown of CYP24A1 enhances the anti-invasion effect of 1α,25(OH)2D3 on mouse ovarian cancer cells by inhibiting EMT[OL].[27 March 2019] http://en.paper.edu.cn/en_releasepaper/content/4748115 |
7. Association between long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus | |||
Li Jun,Pan Haifeng,Ye Dongqing | |||
Preventive Medicine and Hygienics 25 April 2017 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Increasing evidence has demonstrated the association between long noncoding RNAs (lncRNAs) and multiple autoimmune diseases. In this study, we explored four lncRNAs (GAS5, lnc-DC, linc0597 and linc0949) expression levels and gene polymorphisms in systemic lupus erythematosus (SLE). A two stage design was applied. 85 SLE patients and 71 healthy controls were enrolled to investigate the lncRNAs expression levelsin stages one. Then, 860 SLE patients and 831 healthy controls were included to detect the single nucleotide polymorphisms (SNPs) in the differentially expressed lncRNAs in stage two. Expression levels of lncRNAs were detected by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Genotyping was performed using the TaqMan SNP genotyping assays by an EP1 platform. The expression levels of linc0597, lnc-DC and GAS5 were significantly lower in SLE patients than healthy controls (Z=-5.984, P<0.001; Z=-3.703, P<0.001; Z=-2.995, P=0.003 respectively). No significant differences in linc0949 expression level was found between SLE patients and healthy controls (Z=-0.254, P=0.799). The expression levels of linc0597 was significantly decreased in lupus nephritis (LN) compared with SLE patients without nephritis (Z=-2.411, P=0.016). Moreover, the expression level of linc0597 was correlated with systemic lupus erythematosus disease activity. Four SNPs (rs10515177 for lnc-DC; rs2070107, rs2632516, rs2877877 for linc0597) with SLE risk were analyzed. Significant association was observed between the distribution of genotype (CC vs. GG) at SNP rs2070107 and susceptibility to SLE (OR=2.414, 95% CI: 1.266-4.601, P=0.007), and an increased risk was also found in the recessive model (CC vs. CG+GG) (OR=2.415, 95% CI: 1.271-4.590, P=0.007). Furthermore, linc0597 expression level may be associated with the dominant model (CC+CG vs GG) of rs2070107 in the exploration of 34 patients. The association between linc0597 SNPs and SLE as well as its altered expression and correlation with disease activity implicates an important role of this gene in the pathogenesis of SLE. | |||
TO cite this article:Li Jun,Pan Haifeng,Ye Dongqing. Association between long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus[OL].[25 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725288 |
8. Comprehensive long non-coding RNA expression profiling reveals their potential roles in systemic lupus erythematosus | |||
Li Lianju,Ye Dongqing | |||
Preventive Medicine and Hygienics 22 April 2017 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:long non-coding RNAs can regulate gene transcription, modulate protein function, and act as competing endogenous RNA. Yet, their roles in systemic lupus erythematosus remain to be elucidated. We determined the expression profiles of lncRNAs in T cells of SLE patients and healthy controls using microarrays. Up to 1935 lncRNAs and 1977 mRNAs were differentially expressed. QRT-PCR showed downregulated uc001ykl.1 (P=0.004) and ENST00000448942 (P=0.009) in SLE patients. Expression of uc001ykl.1 correlated with erythrocyte sedimentation rate and C-reactive protein, whereas ENST00000448942 level correlated with ESR and anti-Sm antibodies. Short time-series expression miner analysis revealed some lncRNAs whose expressions might correlate with disease activity of SLE patients. Coding-non-coding gene coexpression analyses showed differential lncRNAs might operate via modulating expressions of their correlated, relevant mRNAs in SLE. Differential lncRNAs might also function through their ceRNAs. Our study established that the aberrant expression profiles of lncRNAs may play a role in SLE and thus warrant further investigation. | |||
TO cite this article:Li Lianju,Ye Dongqing. Comprehensive long non-coding RNA expression profiling reveals their potential roles in systemic lupus erythematosus[OL].[22 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725270 |
9. Protective Effect of 1, 25(OH) 2D3 on Glutamate-Induced Cytotoxicity in HT-22 Cell | |||
Ma Shujie,Wang Jianrong,He Jinjiang,Li Bingyan,Zhang Zengli | |||
Preventive Medicine and Hygienics 03 February 2017 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:1,25(OH)2D3 deficiency may be associated with affective disorders, Parkinson's disease, Alzheimer's disease and cognitive abilities. To explore the protective effects of 1,25(OH)2D3 against glutamate-induced damage in a mouse-derived hippocampal HT-22 cells and underlying potential mechanism. The cell survival rate was determined with Cell Counting Kit-8. Cell cycle, apoptosis and reactive oxidative species (ROS) release were detected by FACs technology. Results showed that pretreatment 1,25(OH)2D3 effectively increase HT-22 cell viability up on glutamate exposure. This might be associated with the fact that 1,25(OH)2D3 significantly reduced the percentage of G0/G1 circles (G0/G1%) (p<0.01),increased the proportion of S phase (S%) and G2/M phase (G2/M%) cells (p<0.01). Moreover, apoptosis in HT-22 cells showed the late cell apoptosis rate was decreased (p<0.05) in glutamate group incubated with 1,25(OH)2D3 (i.e. combination group) compared with the glutamate only group. There was an inverse association between the concentration of 1,25(OH)2D3 and apoptosis rate. Meanwhile, the ROS release was elevated in the combination group (p<0.05). Our study indicates that 1,25(OH)2D3 might adversely affect glutamate-induced apoptosis in the HT-22 cells,this might be owing to the fact that 1,25(OH)2D3 could increase cell proliferation and decrease late apoptosis rate. 1,25(OH)2D3 might be a promising therapeutic agent for the treatment of depression. | |||
TO cite this article:Ma Shujie,Wang Jianrong,He Jinjiang, et al. Protective Effect of 1, 25(OH) 2D3 on Glutamate-Induced Cytotoxicity in HT-22 Cell[OL].[ 3 February 2017] http://en.paper.edu.cn/en_releasepaper/content/4718345 |
10. the relationship of five NCDs and physical activity and sedentary behavior of Chinese adults | |||
WANG Wenbin,WEI Qing | |||
Preventive Medicine and Hygienics 15 June 2016 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Objective Explore the relationship between the noncommunicable diseases(NCDs) and physical activity and sedentary in Chinese adults aged 18 to 55 years. Method Use the China Health and Nutrition Survey data, summary NCDs variables,physical activity variables and sedentary variables, then perform statistical analysis and cohort study. Result The relative risk of diabeta of respondents that exercise more than 280 MET a week is 0.32 (95% CI: 1.08 2.18). The relative risk of hypertension of respondents that sit between 14 and 28 hours during leisure time is 1.53 (95% CI: 1.08 2.18).The relative risk of diabeta of respondents that sit under 7 hours during leisure time is 2.41 (95% CI: 1.05 5.53). Conclusion Guarantee 40 MET physical activity every day and sit no more than 2 hours every day can reduce the risk of high blood pressure and diabetes. | |||
TO cite this article:WANG Wenbin,WEI Qing. the relationship of five NCDs and physical activity and sedentary behavior of Chinese adults[OL].[15 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4697731 |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
|
About Sciencepaper Online | Privacy Policy | Terms & Conditions | Contact Us
© 2003-2012 Sciencepaper Online. unless otherwise stated