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	1. Platelet parameters were associated with osteoporosis in large Chinese populations
	SUN Li-Li,LEI Shu-Feng
	Preventive Medicine and Hygienics 16 March 2020
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	Abstract:Purpose Hematological changes related to osteoporosis in elder people are largely unknown. Our aim is to systemically evaluate associations between platelet parameters and osteoporosis in two large Chinese elder populations. Materials and Methods Subjects were selected from our ongoing cohort study: Osteoporosis Preventive Project (OPP), they were 982 from Shishan Community Health Center (Sample 1) and 3675 from Loujiang Community Health Center (Sample 2).The two hospitals used different models of instruments to detect platelet parameters, namely, Mindray BC-5800 automatic five-class blood cell analyzer and Mindray BC-2600 automatic three-class blood cell analyzer. Platelet parameters include platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT). BMD (g/cm2) was measured by dual-energy X-ray absorptiometry with Hologic densitometers (Hologic Inc., USA). We performed the Kruskal-Wallis rank test, Spearman correlation analysis and partial correlation analysis to detect the associations between the platelet parameters and BMD. Results Since most of basic characteristics of the two samples differed significantly (P＜0.001), we separately analyzed the two samples. Among three groups categorized by LS BMD, PLT, PDW, and PCT were significantly different among the three groups. These results were consistent and replicated in the two samples (P<0.05). Similarly, significant differences only for PLT (P=0.003) and PCT (P=0.004) were observed in the Sample 2 among three groups categorized by FN BMD. The PLT and PCT were negatively correlated with LS BMD and FN BMD (P<0.01) in both samples when unadjusted, but after adjustment with sex, age and BMI, only two correlations were still significant (PLT and FN BMD, PCT and FN BMD in the Sample 2). Contrary to PLT and PCT, PDW was positively associated with LS BMD and FN BMD when unadjusted in both samples (P<0.01). However, the significantly positive correlations were only observed in the Sample 2 after adjustment. Conclusion The results suggest that three parameters (PLT, PDW and PCT) have significant correlations with BMD, but MPV has no associations with BMD.
	TO cite this article:SUN Li-Li,LEI Shu-Feng. Platelet parameters were associated with osteoporosis in large Chinese populations[OL].[16 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751215


	2. Knockdown of CYP24A1 enhances the anti-invasion effect of 1α,25(OH)2D3 on mouse ovarian cancer cells by inhibiting EMT
	Xu Jiming,Wang Ping,Hou Yongfeng,Jiang Fei,Li Bingyan
	Preventive Medicine and Hygienics 27 March 2019
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	Abstract:Increasing evidence has shown that epithelial-mesenchymal transition (EMT) can endow cancer cells with motile and invasive properties. In ovarian tissue, EMT not only plays a physiological role in the postovulatory repair of ovary surface epithelial (OSE) cells, but also an important role in the aggressiveness and recurrence of ovarian cancer. Previous research has indicated that 1α,25(OH)2D3 decreases the migration and invasion of many kinds of tumor cells by suppressing EMT. However, it remains unclear whether 1α,25(OH)2D3 can inhibit the process of EMT in mouse OSE (MOSE) cells at different stages of oncogenic transformation. In this study, we found that 1α,25(OH)2D3 significantly reduced the migration and invasion of late malignant transformed MOSE (M-L cells) cells by inhibiting EMT both in vitro and in vivo, but not in intermediate transformed (M-I) cells. Interestingly, the expression of CYP24A1 in M-I cells was distinctly higher than M-L cells following continuous treatment with 1α,25(OH)2D3. Furthermore, we demonstrated that the knockdown of CYP24A1 enhanced the anti-invasion properties of 1α,25(OH)2D3 on both M-I and M-L cells by upregulating the expression of E-cadherin, and downregulating the expression of N-cadherin, Vimentin, β-catenin and Snail. These findings imply that CYP24A1 is a potential target for the inhibition of EMT and ovarian cancer metastasis.
	TO cite this article:Xu Jiming,Wang Ping,Hou Yongfeng, et al. Knockdown of CYP24A1 enhances the anti-invasion effect of 1α,25(OH)2D3 on mouse ovarian cancer cells by inhibiting EMT[OL].[27 March 2019] http://en.paper.edu.cn/en_releasepaper/content/4748115


	3. Current situation of the development of medical group of our country's understanding and thinking
	Niu huanhuan,Miao zhimin
	Preventive Medicine and Hygienics 02 April 2015
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	Abstract:In this paper, the organization and development of the hospital group has solved the problems effectively as following: irrational allocation of medical resources, over-concentration of high quality resources and so on.While how to handle and guide the reform orientation of Chinese Medical Group is still a problem to be solved in the process of development of future due to the fact that Chinese Medical Group is established at elementary step. To explore the applicable operational mode, the author makes the regarding recommendations.
	TO cite this article:Niu huanhuan,Miao zhimin. Current situation of the development of medical group of our country's understanding and thinking[OL].[ 2 April 2015] http://en.paper.edu.cn/en_releasepaper/content/4636872


	4. Research Progress on Healthy City Index System
	XU Yuan,DING Hui,WEI Renmin
	Preventive Medicine and Hygienics 25 March 2015
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	Abstract:This article introduced the concept and development of healthy city ,discusses the construction of the evaluation index system ."Healthy City"was introduced to China in 1990s, the nature of which is an organic integration of healthy people, healthy environment and healthy society. Healthy City is a new reform to traditional economic development model and should be an important goal of China's urban growth. It is necessary to build a set of scientific and logical evaluation index sysem for the development of healthy city.
	TO cite this article:XU Yuan,DING Hui,WEI Renmin. Research Progress on Healthy City Index System[OL].[25 March 2015] http://en.paper.edu.cn/en_releasepaper/content/4635405


	5. Effects of BmKNJX11, a bioactive polypeptide purified from Buthus martensi Karsch, on TTX-R sodium channels in rat dorsal root ganglion neurons
	Xijie Wang,Peng Xu,Shanshan An,Qin Sun,Jie Cheng,Rong Gao,Hang Xiao
	Preventive Medicine and Hygienics 28 July 2009
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	Abstract:BmKNJX11is a 7036.85 Da polypeptide purified from the venom of Asian scorpion Buthus martensi Karsch (BmK). With whole cell recording, BmKNJX11 inhibited tetrodotoxin- resistant voltage-gated sodium channels (TTX-R VGSC) in freshly isolated rat dorsal root ganglion (DRG) neurons in a concentration- and voltage-dependent manner. At a concentration of 40 μg/ml BmKNJX11 increased the activation threshold and produced positive shifting of TTX-R sodium current (INa) activation curve. In addition, BmKNJX11 induced shifting of the steady-state inactivation curve to left, delayed the recovery of TTX-R INa from inactivation, and also reduced the fraction of available sodium channels. These results suggested that BmKNJX11 might exert effects on VGSC by binding to a specific site. Considering that TTX-R VGSC expressed in DRG neurons play a critical role in nociceptive transmission, the interaction of BmKNJX11 with TTX-R VGSC might lead to a change in excitability of nociceptive afferent fibers which may be involved in the observed peripheral pain expression.
	TO cite this article:Xijie Wang,Peng Xu,Shanshan An, et al. Effects of BmKNJX11, a bioactive polypeptide purified from Buthus martensi Karsch, on TTX-R sodium channels in rat dorsal root ganglion neurons[OL].[28 July 2009] http://en.paper.edu.cn/en_releasepaper/content/34118

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