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	1. HAS2 Promotes Pancreatic Stellate Cells Activation under TGF-β1/MeCP2 Axis in Chronic Pancreatitis
	LI Ruiping,ZHU Jianwei,PENG Xue,LIU Miaoru,FAN Zijun,CAI Zixuan,SHE Yuanling,GONG Zhenyun,ZHAO Jing,HU Duanmin
	Clinical Medicine 14 April 2023
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	Abstract:The pathogenesis of chronic pancreatitis (CP) remains unclear. Few studies have investigated the role of hyaluronic acid synthetase 2 (HAS2) in CP tissue and its effects on pancreatic stellate cells (PSCs). The purpose of this study was to investigate the effect of HAS2 on the occurrence and development of CP fibrosis through the activation of PSCs. Firstly, the effects of up-regulation and down-regulation of HAS2 on α-smooth muscle actin (α-SMA) expression in PSCs were investigated by RT-qPCR and Western blotting. Secondly, the regulatory effects of HAS2 on the fibroblast phenotype of PSCs were investigated by cell wound healing assay, transwell assay and CCK-8 assay. Then, the rescue assay was used to investigate whether HAS2 was regulated by the TGF-β1/MeCP2 axis. Finally, the CP rat model was constructed to explore whether the expression of HAS2 and MeCP2 was increased, and Pearson linear correlation was used to investigate the correlation between the expression level of HAS2 and the degree of pancreatic fibrosis. The results revealed that HAS2 promoted α-SMA expression in PSCs, and the down-regulation of HAS2 inhibited the migration and proliferation of PSCs. Knockdown of HAS2 in PSCs inhibits MeCP2-induced α-SMA expression and HAS2 is regulated by TGF-β1/MeCP2 axis. The expressions of HAS2 and MeCP2 were increased in CP model rats compared with the control group, and the expression levels of HAS2 were positively correlated with degree of pancreatic fibrosis. In conclusion, HAS2 can induce PSCs to activate and maintain the fibrotic phenotype of PSCs, and this effect is regulated by TGF-β1/MeCP2 axis.
	TO cite this article:LI Ruiping,ZHU Jianwei,PENG Xue, et al. HAS2 Promotes Pancreatic Stellate Cells Activation under TGF-β1/MeCP2 Axis in Chronic Pancreatitis[OL].[14 April 2023] http://en.paper.edu.cn/en_releasepaper/content/4760270


	2. Teriparatide in the treatment of osteoradionecrosis of the jaws: a controlled clinical trial
	Hao Nie,Weihong Wang,Biao Xu,Jingyi Li,Yu Liu,Yemei Qian
	Clinical Medicine 14 February 2023
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	Abstract:Objective: To investigate the clinical therapeutic effect of teriparatide on osteoradionecrosis of the jaws (ORNJ). Materials and Methods: From May 2021 to November 2022, altogether 17 patients with ORNJ who consulted were divided into teriparatide and control groups. Following basic treatment including lesion removal, teriparatide group received subcutaneous administration of the drug (20ug/d) for two months, whereas control group received basic treatment only (including lesion excision.). Finally, patients underwent wound healing and jaw bone regeneration in the region of necrotic bone under observation. Results: There were seven patients in control group and ten in teriparatide group. In the course of treatment, two patients in teriparatide group withdrew from the research due to drug allergy and stroke, while the remaining eight experienced no side effects. A significant amount of new bone regeneration was observed in the region of dead bone in five patients in the teriparatide group, and their healing rate (37.5%) was higher than that of control group (14.2%) (P<0.001). Conclusion: Teriparatide can improve wound healing and new bone regeneration in patients with ORNJ after the removal of moribund bone from ORNJ.
	TO cite this article:Hao Nie,Weihong Wang,Biao Xu, et al. Teriparatide in the treatment of osteoradionecrosis of the jaws: a controlled clinical trial[OL].[14 February 2023] http://en.paper.edu.cn/en_releasepaper/content/4759022


	3. Key Differential Gene Analysis between Ewing Sarcoma Cado-Es1 Cell Line Tumor Stem Cells, Non-Tumor Stem Cells, and Mesenchymal Stem Cells
	Hongliang Wu,Sihang Zheng,Qun He,Yan Li
	Clinical Medicine 24 March 2022
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	Abstract:Background Ewing sarcoma is a highly malignant tumor. It is of great significance to identify new biomarkers or therapeutic targets. This study aimed to analyze the differentially expressed genes between Ewing sarcoma ERG type cell line cado-es1 tumor stem cell like cells, non-tumor stem cell like cells and mesenchymal stem cells (MSC) derived from Ewing sarcoma patients, and study the key genes related to Ewing sarcoma ERG type. Methods The NCBI SRA database data ERP104460 was retrieved, and three groups of MSC cells, tumor stem cell like cells (SP group) and non-tumor stem cell like cells (nsp group) obtained from different Ewing sarcoma patients were selected. The RNA-seq data of 9 samples in each group were analyzed to screen the significantly differentially expressed genes. Pathway enrichment analysis and the protein-protein interaction network was performed, and the hub genes were screened. Results Compared with MSC group, 8286 differentially expressed genes were obtained, including 3638 up-regulated genes and 4648 down-regulated genes. There were 9097 differentially expressed genes in nsp group compared with msc group, including 4800 up-regulated genes and 4297 down regulated genes. Compared with nsp group, four differentially expressed genes were obtained, including three up-regulated genes, U2, SNORA45b and RNU2-1. One down regulated gene was MTND1P27. These differentially expressed genes are mainly involved in biological processes and biological pathways such as cell division, cell cycle and DNA replication. By GO, KEGG and protein interaction network, 10 hub genes including THBS1, POSTN, COL1A1, COL1A2, MMP2, MMP14, SPARC, DCN, SPP1 and COL3A1 were screened in sp vs msc group; 10 hub genes including THBS1, MMP2, LOX, POSTN, COL1A1, COL1A2, MMP14, SPARC, DCN and SPP1 were obtained in nsp vs msc group. The key differential genes of PPI network between sp vs msc group and nsp vs msc group were COL3A1 and LOX. Conclusion THBS1, POSTN, COL1A1, COL1A2, MMP2, MMP14, SPARC, DCN, SPP1 and COL3A1 are key hub genes in Ewing sarcoma tumor stem cell like cells; THBS1, MMP2, LOX, POSTN, COL1A1, COL1A2, MMP14, SPARC, DCN and SPP1 are key hub genes in non-tumor stem cell like cells of Ewing sarcoma.
	TO cite this article:Hongliang Wu,Sihang Zheng,Qun He, et al. Key Differential Gene Analysis between Ewing Sarcoma Cado-Es1 Cell Line Tumor Stem Cells, Non-Tumor Stem Cells, and Mesenchymal Stem Cells[OL].[24 March 2022]

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