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| There are 234 papers published in subject: since this site started. | |||
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| 1. HAS2 Promotes Pancreatic Stellate Cells Activation under TGF-β1/MeCP2 Axis in Chronic Pancreatitis | |||
| LI Ruiping,ZHU Jianwei,PENG Xue,LIU Miaoru,FAN Zijun,CAI Zixuan,SHE Yuanling,GONG Zhenyun,ZHAO Jing,HU Duanmin | |||
Clinical Medicine 14 April 2023
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| Abstract:The pathogenesis of chronic pancreatitis (CP) remains unclear. Few studies have investigated the role of hyaluronic acid synthetase 2 (HAS2) in CP tissue and its effects on pancreatic stellate cells (PSCs). The purpose of this study was to investigate the effect of HAS2 on the occurrence and development of CP fibrosis through the activation of PSCs. Firstly, the effects of up-regulation and down-regulation of HAS2 on α-smooth muscle actin (α-SMA) expression in PSCs were investigated by RT-qPCR and Western blotting. Secondly, the regulatory effects of HAS2 on the fibroblast phenotype of PSCs were investigated by cell wound healing assay, transwell assay and CCK-8 assay. Then, the rescue assay was used to investigate whether HAS2 was regulated by the TGF-β1/MeCP2 axis. Finally, the CP rat model was constructed to explore whether the expression of HAS2 and MeCP2 was increased, and Pearson linear correlation was used to investigate the correlation between the expression level of HAS2 and the degree of pancreatic fibrosis. The results revealed that HAS2 promoted α-SMA expression in PSCs, and the down-regulation of HAS2 inhibited the migration and proliferation of PSCs. Knockdown of HAS2 in PSCs inhibits MeCP2-induced α-SMA expression and HAS2 is regulated by TGF-β1/MeCP2 axis. The expressions of HAS2 and MeCP2 were increased in CP model rats compared with the control group, and the expression levels of HAS2 were positively correlated with degree of pancreatic fibrosis. In conclusion, HAS2 can induce PSCs to activate and maintain the fibrotic phenotype of PSCs, and this effect is regulated by TGF-β1/MeCP2 axis. | |||
| TO cite this article:LI Ruiping,ZHU Jianwei,PENG Xue, et al. HAS2 Promotes Pancreatic Stellate Cells Activation under TGF-β1/MeCP2 Axis in Chronic Pancreatitis[OL].[14 April 2023] http://en.paper.edu.cn/en_releasepaper/content/4760270 | |||
| 2. Teriparatide in the treatment of osteoradionecrosis of the jaws: a controlled clinical trial | |||
| Hao Nie,Weihong Wang,Biao Xu,Jingyi Li,Yu Liu,Yemei Qian | |||
| Clinical Medicine 14 February 2023 | |||
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| Abstract:Objective: To investigate the clinical therapeutic effect of teriparatide on osteoradionecrosis of the jaws (ORNJ). Materials and Methods: From May 2021 to November 2022, altogether 17 patients with ORNJ who consulted were divided into teriparatide and control groups. Following basic treatment including lesion removal, teriparatide group received subcutaneous administration of the drug (20ug/d) for two months, whereas control group received basic treatment only (including lesion excision.). Finally, patients underwent wound healing and jaw bone regeneration in the region of necrotic bone under observation. Results: There were seven patients in control group and ten in teriparatide group. In the course of treatment, two patients in teriparatide group withdrew from the research due to drug allergy and stroke, while the remaining eight experienced no side effects. A significant amount of new bone regeneration was observed in the region of dead bone in five patients in the teriparatide group, and their healing rate (37.5%) was higher than that of control group (14.2%) (P<0.001). Conclusion: Teriparatide can improve wound healing and new bone regeneration in patients with ORNJ after the removal of moribund bone from ORNJ. | |||
| TO cite this article:Hao Nie,Weihong Wang,Biao Xu, et al. Teriparatide in the treatment of osteoradionecrosis of the jaws: a controlled clinical trial[OL].[14 February 2023] http://en.paper.edu.cn/en_releasepaper/content/4759022 | |||
| 3. Key Differential Gene Analysis between Ewing Sarcoma Cado-Es1 Cell Line Tumor Stem Cells, Non-Tumor Stem Cells, and Mesenchymal Stem Cells | |||
| Hongliang Wu,Sihang Zheng,Qun He,Yan Li | |||
| Clinical Medicine 24 March 2022 | |||
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| Abstract:Background Ewing sarcoma is a highly malignant tumor. It is of great significance to identify new biomarkers or therapeutic targets. This study aimed to analyze the differentially expressed genes between Ewing sarcoma ERG type cell line cado-es1 tumor stem cell like cells, non-tumor stem cell like cells and mesenchymal stem cells (MSC) derived from Ewing sarcoma patients, and study the key genes related to Ewing sarcoma ERG type. Methods The NCBI SRA database data ERP104460 was retrieved, and three groups of MSC cells, tumor stem cell like cells (SP group) and non-tumor stem cell like cells (nsp group) obtained from different Ewing sarcoma patients were selected. The RNA-seq data of 9 samples in each group were analyzed to screen the significantly differentially expressed genes. Pathway enrichment analysis and the protein-protein interaction network was performed, and the hub genes were screened. Results Compared with MSC group, 8286 differentially expressed genes were obtained, including 3638 up-regulated genes and 4648 down-regulated genes. There were 9097 differentially expressed genes in nsp group compared with msc group, including 4800 up-regulated genes and 4297 down regulated genes. Compared with nsp group, four differentially expressed genes were obtained, including three up-regulated genes, U2, SNORA45b and RNU2-1. One down regulated gene was MTND1P27. These differentially expressed genes are mainly involved in biological processes and biological pathways such as cell division, cell cycle and DNA replication. By GO, KEGG and protein interaction network, 10 hub genes including THBS1, POSTN, COL1A1, COL1A2, MMP2, MMP14, SPARC, DCN, SPP1 and COL3A1 were screened in sp vs msc group; 10 hub genes including THBS1, MMP2, LOX, POSTN, COL1A1, COL1A2, MMP14, SPARC, DCN and SPP1 were obtained in nsp vs msc group. The key differential genes of PPI network between sp vs msc group and nsp vs msc group were COL3A1 and LOX. Conclusion THBS1, POSTN, COL1A1, COL1A2, MMP2, MMP14, SPARC, DCN, SPP1 and COL3A1 are key hub genes in Ewing sarcoma tumor stem cell like cells; THBS1, MMP2, LOX, POSTN, COL1A1, COL1A2, MMP14, SPARC, DCN and SPP1 are key hub genes in non-tumor stem cell like cells of Ewing sarcoma. | |||
| TO cite this article:Hongliang Wu,Sihang Zheng,Qun He, et al. Key Differential Gene Analysis between Ewing Sarcoma Cado-Es1 Cell Line Tumor Stem Cells, Non-Tumor Stem Cells, and Mesenchymal Stem Cells[OL].[24 March 2022] http://en.paper.edu.cn/en_releasepaper/content/4757042 | |||
| 4. Recent Advances of Circular RNA as a Potential Diagnostic and Therapeutic Target for Osteosarcoma | |||
| Wu Hongliang,Zheng Sihang,Li Yan | |||
| Clinical Medicine 23 March 2022 | |||
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| Abstract:Osteosarcoma is the most common primary malignant bone tumor, which is prone to early metastasis and poor prognosis. The current treatment methods need to be improved. Circular RNA is a covalently blocked circular endogenous non-coding RNA, which plays an essential role in the occurrence, development, clinical diagnosis, and treatment of various diseases. Understanding its role in osteosarcoma is conducive to the early detection, diagnosis, and treatment of osteosarcoma. In this paper, we reviewed the mechanism of action of circular RNA in the occurrence and development of osteosarcoma and its clinical application in recent years. | |||
| TO cite this article:Wu Hongliang,Zheng Sihang,Li Yan. Recent Advances of Circular RNA as a Potential Diagnostic and Therapeutic Target for Osteosarcoma[OL].[23 March 2022] http://en.paper.edu.cn/en_releasepaper/content/4756972 | |||
| 5. Measurement and correlation analysis of upper airway and mandible, hyoid in patients with bilateral anterior disc displacement | |||
| Hou Yijun,Pan Xiaojing | |||
| Clinical Medicine 23 March 2022
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| Abstract:Objective: To evaluate the presence of upper airway stenosis in patients with bilateral anterior disc displacement, and to further demonstrate the relationship between temporomandibular joint, airway, and hyoid bone. Methods: 64 patients with bilateral anterior disc displacement shown by CBCT in the joint specialty of Stomatological Hospital of Lanzhou University from June 2020 to August 2021 were selected as the patient group, 65 patients with normal joints diagnosed by arthrologists were selected as the control group. The included patients were 18-44 years old, with normal BMI index and skeletal class I. The number of patients with high angle and low angle in the experimental group was the same as that in the control group. First, Dolphin11.8 was used to measure joint space, airway volume, and cross-sectional area. It also reconstructed lateral cranial radiographs were used to measure the parameters of the mandibular and hyoid bone. last, we analyzed the correlation. Results: There was no difference in segmentation parameters among all patients. In patients with bilateral anterior disc displacement, the airway is narrow, the mandible retracts, and the hyoid bone is lower and more posterior. The linear ratio of condylar sagittal position （LR） was correlated with the airway volume of palatopharynx and glossopharynx, and with the length of the mandibular body and the sagittal position of mandible. Conclusions: Patients with bilateral anterior disc displacement and patients with OSAHS show similar changes in the position of mandible and hyoid bone. When meeting patients with joint problems, stomatologists should pay attention to asking them whether they have problems with airway obstruction. | |||
| TO cite this article:Hou Yijun,Pan Xiaojing. Measurement and correlation analysis of upper airway and mandible, hyoid in patients with bilateral anterior disc displacement[OL].[23 March 2022] http://en.paper.edu.cn/en_releasepaper/content/4757016 | |||
| 6. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens | |||
| Hui Wang,Zhanhai Yu,Zhiqiang Li,Jianye Zhou | |||
Clinical Medicine 20 October 2021
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| Abstract:As a kind of symbiotic bacteria, Streptococcus sanguinis is widely distributed in the oral cavity, mainly including the surface of teeth, oral mucosa , and human saliva. Besides, as one of the initially colonized strains, Streptococcus sanguinis is the pioneer and key role in the development of oral biofilms, which is believed to resist pathogens and promote oral health. And the evolution of its biofilms plays an important part in both bacterial adaptations to the environment and invasion of the host. This paper discusses the early colonization mechanism of Streptococcus sanguinis and its interaction with pathogens related to caries and periodontitis, and finally, summarizes the methods of biofilm research, hoping to provide ideas for the follow-up research in this field. | |||
| TO cite this article:Hui Wang,Zhanhai Yu,Zhiqiang Li, et al. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens[OL].[20 October 2021] http://en.paper.edu.cn/en_releasepaper/content/4755640 | |||
| 7. Evaluation of alveolar bone density and thickness of the mandibular molars in patients with periodontitis | |||
| ABEER A AL-Sosowa,MOHAMMED N Alhajj,EHAB A.Abdulghani,ZHE He,PANG Yunqing,LI Na,WANG Jing | |||
| Clinical Medicine 29 May 2021 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:Background: Periodontitis is the main cause of tooth loss in adults and is closely related to many diseases throughout the body. The main purpose of this study is to use Cone beam computed tomography (CBCT) to study the difference in alveolar bone density and thickness of mandibular molars in patients with periodontitis in Gansu, in order to provide guidance for treatment plans for patients with periodontitis. Methods: CBCT was used to evaluate the buccal and lingual alveolar bone loss, bone density and bone thickness of 668 mandibular molars (344 periodontal healthy teeth and 324 periodontitis teeth) of 167 subjects. Compare the changes in alveolar bone density and thickness between healthy individuals and patients with periodontitis, and explore its relationship with tooth type, tooth surface, root position, degree of bone loss, age and gender. Results: The alveolar bone density and thickness of healthy individuals were higher than those of periodontitis patients, but only the buccal bone thickness was statistically significant (P<0.01). There were significant differences in alveolar bone density and thickness between the left and right molars, between the first molar and the second molar, and between the mesial and distal surfaces of the molars between healthy periodontal patients and patients with periodontitis (P<0.01) . For periodontitis patients, the buccal bone density and thickness between different degrees of alveolar bone loss have significant differences (P<0.01). There were significant differences in alveolar bone density between periodontal healthy individuals and periodontitis patients of different genders and ages (P<0.01). However, the thickness of the alveolar bone of periodontitis patients of different genders and ages were significantly different (P<0.01). Gender had a significant effect on the lingual alveolar bone density of periodontal healthy individuals and periodontitis patients (P<0.01). The tooth type, tooth surface and tooth root mesial and distal faces had significant effects on the alveolar bone thickness of periodontal healthy individuals and periodontitis patients (P<0.01). Conclusion: The thickness of alveolar bone in healthy periodontal patients is significantly higher than that in patients with periodontitis. The alveolar bone density and thickness of periodontal healthy individuals and periodontitis patients are affected by many factors. | |||
| TO cite this article:ABEER A AL-Sosowa,MOHAMMED N Alhajj,EHAB A.Abdulghani, et al. Evaluation of alveolar bone density and thickness of the mandibular molars in patients with periodontitis[OL].[29 May 2021] http://en.paper.edu.cn/en_releasepaper/content/4755079 | |||
| 8. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion | |||
| ZHAO Wei,AN Xiaoli | |||
Clinical Medicine 02 May 2019
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| Abstract:Purpose: To evaluate and compare the skeletal and facial changes of children with mild skeletal Class III malocclusion following the treatment of the Function Regulator III appliance and the Sander III appliance. Materials and methods: The study sample consisted of 40 children presenting skeletal Class III malocclusion. The group of patients treated with the Function Regulator III appliances (FR-III) consisted of 20 subjects with a mean age of 7.615±0.9996 years. The group of patients treated with the Sander III appliances (SD-III) consisted of 20 subjects with a mean age of 7.68±1.0665 years. Lateral cephalograms were obtained immediately before initiation and after completion of the treatment. Twenty-one variables were used for the analysis of skeletal and lateral profile changes. The non-parametric test was utilized to evaluate the presence of significant changes (P < 0.05). Results: Cephalometric analysis showed that the ANB angle increased by 4.05o in the SD-III group, compared with 1.46o in the FR-III group (p < 0.0001). There was 1.93o and 5.75o increase in GoGn-SN and FMA respectively in SD-III group, and the trends in FR-III group were similar, but there was no statistical difference between the two groups(p＞0.05). Conclusion: SD-III is suitable for the maxillary deficiency of skeletal Class III malocclusion with low or average mandibular plane angle, rather than the high angle patients with apparent mandibular overgrowth. FR-III is suitable for the functional crossbite with low or average angle and the patients of mild skeletal Class III malocclusion with normal upper and lower jaws. | |||
| TO cite this article:ZHAO Wei,AN Xiaoli. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion[OL].[ 2 May 2019] http://en.paper.edu.cn/en_releasepaper/content/4748845 | |||
| 9. GDPD5 Immune Inflammation-Mediated Angiogenesis and Invasion Regulation Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation | |||
| XUE Shuaidong,WANG Ling,HUANG Juxiang | |||
Clinical Medicine 12 November 2018
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| Abstract:We data-analyzed and constructed the high-expression GDPD5 immune inflammation-mediated angiogenesis and invasion regulation network in human hepatocellular carcinoma (HCC) compared with low-expression (fold change≥2) no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) in GEO data set, by using integration of gene regulatory network inference method with gene ontology (GO). Our result showed that GDPD5 immune inflammation and multi-regulation upstream network BIRC5, BRCA1, CDKN3, EYA1, HOXD4, LEF1, PLA2G1B, PROK1, PTHLH, ROBO1, SCML2, REG3A activated GDPD5, and downstream GDPD5-activated CAD, CDC2, CDKN3, DKK1, E2F1, FOXM1, HMGB2, MAP2, MYCN, MYH6, NEK2, NR5A1, PROK1 in HCC. We proposed that GDPD5 activated network enhanced blood coagulation, chemotaxis, inflammatory response, interleukin-8 production, leukocyte migration, neutrophil chemotaxis, neutrophil mediated immunity, receptor mediated endocytosis, positive regulation of DNA repair, positive regulation of protein ubiquitination, as a result of inducing immune inflammation-mediated angiogenesis and invasion regulation in HCC. Our hypothesis was verified by GDPD5 regulation subnetwork containing angiogenesis, cell proliferation, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter, Wnt receptor signaling pathway; also by GDPD5 negative regulation subnetwork including centriole replication, fatty acid biosynthesis, transcription, cell-cell adhesion, microtubule depolymerization in HCC, respectively. | |||
| TO cite this article:XUE Shuaidong,WANG Ling,HUANG Juxiang. GDPD5 Immune Inflammation-Mediated Angiogenesis and Invasion Regulation Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation[OL].[12 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746448 | |||
| 10. Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10 | |||
| Cui-Xiang Xu,Zhan-Kui Jin,Pu-Xun Tian | |||
| Clinical Medicine 09 May 2018 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:Background/Aims: Biomarkers are urgently required for predicting rejection and for early anti-rejection treatment to prevent the functional impairment of the graft. We hypothesized that the combination of circulating fractalkine, IFN-γ and IP-10 might serve as effective biomarkers for predicting early acute rejection. Methods: We conducted a retrospective study of 87 subjects, who were classified into acute rejection group (ARG; n=38) and non-rejection group (NRG; n=49). Serum fractalkine, IFN-γ and IP-10 levels were measured by Luminex. Results: The levels of fractalkine on day 0, IP-10 on 4th day, fractalkine, IFN-γ and IP-10 on the 7th day in ARG was significantly higher than that in NRG. Kaplan-Meier survival analysis highlighted the higher-levels of fractalkine on day 0, 4th and 7th day, IFN-γ on day 0, 1st, 4th, and 7th day and IP-10 on the 4th and 7th day in rejection-free survival probability were significantly lower than low-levels. ROC analyses highlight the superiority of fractalkine on day 0, IP-10 on day 0, 4th and 7th day, and IFN-γ on day 0, 1st and 7th day in prediction of acute rejection. We found the combination of fractalkine on day 0, IP-10 on 7th day and IFN-γ on 7th day had the highest AUC (0.866) for predicting rejection with a sensitivity of 86.8% and a specificity of 89.8%. Conclusion: Our findings demonstrated a more powerful prediction of early acute renal allograft rejection by combination of multiple-biomarkers of fractalkine, IFN-γ and IP-10, and the results might help stratify the immunologic risk of acute allograft rejection in patients.????? | |||
| TO cite this article:Cui-Xiang Xu,Zhan-Kui Jin,Pu-Xun Tian. Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10[OL].[ 9 May 2018] http://en.paper.edu.cn/en_releasepaper/content/4745000 | |||
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