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	1. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion
	ZHAO Wei,AN Xiaoli
	Clinical Medicine 02 May 2019
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (476K B)

	Abstract:Purpose: To evaluate and compare the skeletal and facial changes of children with mild skeletal Class III malocclusion following the treatment of the Function Regulator III appliance and the Sander III appliance. Materials and methods: The study sample consisted of 40 children presenting skeletal Class III malocclusion. The group of patients treated with the Function Regulator III appliances (FR-III) consisted of 20 subjects with a mean age of 7.615±0.9996 years. The group of patients treated with the Sander III appliances (SD-III) consisted of 20 subjects with a mean age of 7.68±1.0665 years. Lateral cephalograms were obtained immediately before initiation and after completion of the treatment. Twenty-one variables were used for the analysis of skeletal and lateral profile changes. The non-parametric test was utilized to evaluate the presence of significant changes (P < 0.05). Results: Cephalometric analysis showed that the ANB angle increased by 4.05o in the SD-III group, compared with 1.46o in the FR-III group (p < 0.0001). There was 1.93o and 5.75o increase in GoGn-SN and FMA respectively in SD-III group, and the trends in FR-III group were similar, but there was no statistical difference between the two groups(p＞0.05). Conclusion: SD-III is suitable for the maxillary deficiency of skeletal Class III malocclusion with low or average mandibular plane angle, rather than the high angle patients with apparent mandibular overgrowth. FR-III is suitable for the functional crossbite with low or average angle and the patients of mild skeletal Class III malocclusion with normal upper and lower jaws.
	TO cite this article:ZHAO Wei,AN Xiaoli. Comparative study of the treatment effects with FR III and Sander III appliances in children with Class III malocclusion[OL].[ 2 May 2019] http://en.paper.edu.cn/en_releasepaper/content/4748845


	2. GDPD5 Immune Inflammation-Mediated Angiogenesis and Invasion Regulation Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation
	XUE Shuaidong,WANG Ling,HUANG Juxiang
	Clinical Medicine 12 November 2018
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (456K B)

	Abstract:We data-analyzed and constructed the high-expression GDPD5 immune inflammation-mediated angiogenesis and invasion regulation network in human hepatocellular carcinoma (HCC) compared with low-expression (fold change≥2) no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) in GEO data set, by using integration of gene regulatory network inference method with gene ontology (GO). Our result showed that GDPD5 immune inflammation and multi-regulation upstream network BIRC5, BRCA1, CDKN3, EYA1, HOXD4, LEF1, PLA2G1B, PROK1, PTHLH, ROBO1, SCML2, REG3A activated GDPD5, and downstream GDPD5-activated CAD, CDC2, CDKN3, DKK1, E2F1, FOXM1, HMGB2, MAP2, MYCN, MYH6, NEK2, NR5A1, PROK1 in HCC. We proposed that GDPD5 activated network enhanced blood coagulation, chemotaxis, inflammatory response, interleukin-8 production, leukocyte migration, neutrophil chemotaxis, neutrophil mediated immunity, receptor mediated endocytosis, positive regulation of DNA repair, positive regulation of protein ubiquitination, as a result of inducing immune inflammation-mediated angiogenesis and invasion regulation in HCC. Our hypothesis was verified by GDPD5 regulation subnetwork containing angiogenesis, cell proliferation, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter, Wnt receptor signaling pathway; also by GDPD5 negative regulation subnetwork including centriole replication, fatty acid biosynthesis, transcription, cell-cell adhesion, microtubule depolymerization in HCC, respectively.
	TO cite this article:XUE Shuaidong,WANG Ling,HUANG Juxiang. GDPD5 Immune Inflammation-Mediated Angiogenesis and Invasion Regulation Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation[OL].[12 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746448


	3. Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10
	Cui-Xiang Xu,Zhan-Kui Jin,Pu-Xun Tian
	Clinical Medicine 09 May 2018
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (894K B)

	Abstract:Background/Aims: Biomarkers are urgently required for predicting rejection and for early anti-rejection treatment to prevent the functional impairment of the graft. We hypothesized that the combination of circulating fractalkine, IFN-γ and IP-10 might serve as effective biomarkers for predicting early acute rejection. Methods: We conducted a retrospective study of 87 subjects, who were classified into acute rejection group (ARG; n=38) and non-rejection group (NRG; n=49). Serum fractalkine, IFN-γ and IP-10 levels were measured by Luminex. Results: The levels of fractalkine on day 0, IP-10 on 4th day, fractalkine, IFN-γ and IP-10 on the 7th day in ARG was significantly higher than that in NRG. Kaplan-Meier survival analysis highlighted the higher-levels of fractalkine on day 0, 4th and 7th day, IFN-γ on day 0, 1st, 4th, and 7th day and IP-10 on the 4th and 7th day in rejection-free survival probability were significantly lower than low-levels. ROC analyses highlight the superiority of fractalkine on day 0, IP-10 on day 0, 4th and 7th day, and IFN-γ on day 0, 1st and 7th day in prediction of acute rejection. We found the combination of fractalkine on day 0, IP-10 on 7th day and IFN-γ on 7th day had the highest AUC (0.866) for predicting rejection with a sensitivity of 86.8% and a specificity of 89.8%. Conclusion: Our findings demonstrated a more powerful prediction of early acute renal allograft rejection by combination of multiple-biomarkers of fractalkine, IFN-γ and IP-10, and the results might help stratify the immunologic risk of acute allograft rejection in patients.?????
	TO cite this article:Cui-Xiang Xu,Zhan-Kui Jin,Pu-Xun Tian. Multiple-biomarkers provide powerful prediction of early acute renal allograft rejection by combination of serum fractalkine, IFN-γ and IP-10[OL].[ 9 May 2018] http://en.paper.edu.cn/en_releasepaper/content/4745000


	4. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis
	Wang Tiantian,Yuan Xuemin,Zhang Xingxing,LI Yue,Pang Yunqing,Wang Xuemei,Wang Jing
	Clinical Medicine 20 April 2018
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (457K B)

	Abstract: Background: Chronic periodontitis are associated with the resorption of alveolar bone. Sclerostin participates in the process of bone resorption through the RANKL/RANK/OPG pathway. However, the mechanism of bone resorption and sclerostin expression in chronic periodontitis is unclear. In this study, the purpose was to evaluate the mechanism of action of sclerostin in human chronic periodontitis. Methods: Saliva and gingival crevicular fluid were collected from systemically healthy non-periodontitis (n=30) and chronic periodontitis subjects (n=30). The protein levels of sclerostin, RANKL and OPG in saliva and gingival crevicular fluid were detected by enzyme linked immunosorbent assay (ELISA). Results: Sclerostin levels in saliva and gingival crevicular fluid were significantly higher in the chronic periodontitis group than the non-periodontitis group (P < 0.05). The level of OPG is significantly lower but the RANKL level and the ratio of RANKL/OPG was significantly higher than that in the non-periodontitis group in saliva and gingival crevicular fluid (P < 0.05). Sclerostin levels in saliva and gingival crevicular fluid were significantly positively correlated with PD, CAL and BOP (P < 0.05). Conclusions: The results showed that sclerostin may affect bone tissue damage of chronic periodontitis through RANKL/RANK/OPG pathway. It will provide a new insight into the diagnosis and treatment of periodontitis patients.
	TO cite this article:Wang Tiantian,Yuan Xuemin,Zhang Xingxing, et al. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis[OL].[20 April 2018] http://en.paper.edu.cn/en_releasepaper/content/4744647


	5. The roles of serine racemase in excitotoxicity: implication in diabetic retinopathy
	Haiyan Jiang,He Zhang,Shengzhou Wu
	Clinical Medicine 17 April 2018
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (209K B)

	Abstract:Excitotoxicity is a pathologic process when excitatory amino acids such as glutamate kill neurons or nerve; this process is largely ascribed to over-activation of glutamate receptors including the NMDA/non-NMDA receptors. Activation of the NMDA receptor is dependent on the binding of glutamate to GluN2 subunit and of D-serine/glycine to GluN1 subunit. Excitotoxicity accounts for neurodegeneration in stroke, traumatic brain injury, neurodegenerative diseases including Alzheimer\'s disease and amyotrophic lateral sclerosis, even in diabetic retinopathy (DR). DR is characterized with retinal neurodegeneration and retinal microvascular abnormalities; a plethora of data indicate that retinal neurodegeneration precedes microvascular abnormalities. In the last decade, neurodegeneration in DR has been highlighted; inflammation and oxidation due to hyperglycemia have been connected with retinal neuronal loss. Although the underlying mechanisms remain elusive, convincing data suggest the critical role of over-activation of NMDAR underlying retinal neurodegeneration. Recent data including ours demonstrate that overexpression of serine racemase and excessive D-serine contributes to neurodegeneration in DR; SR deficiency significantly rescues this retinal neuropathy. Herein, the role of serine racemase in excitotoxicity and the contribution to retinal neurodegeneration in DR have been reviewed.
	TO cite this article:Haiyan Jiang,He Zhang,Shengzhou Wu. The roles of serine racemase in excitotoxicity: implication in diabetic retinopathy[OL].[17 April 2018] http://en.paper.edu.cn/en_releasepaper/content/4744636


	6. Derivation of a 17 myocardial segment angiographic scoring system and its validation
	XU Mingxing,HE Yongming
	Clinical Medicine 09 September 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (1527K B)

	Abstract:The Syntax Score has been devised to characterize the number of lesions, and their functional impact, location, and complexity in terms of coronary artery trees. An obvious fallacy is that the Syntax Score system over simply divided coronary artery circulation system into right or left dominant coronary artery circulation, which fails to reflect the great variability of coronary artery trees. Furthermore, the Syntax Score is in essence blood vessel-based rather than blood vessel importance-based. Finally, the scores assigned for the lesion characteristics, such as calcification, tortuosity, angulation, and thrombosis, etc, are largely arbitrary in the Syntax score. In the current study, we have aimed to devise a new scoring system, the 17 myocardial segment based coronary scoring system, to accurately describe the anatomical characteristics of the native coronary artery trees, to grade the complexity of the acquired coronary artery diseases according to the importance of a blood vessel, and to collect the treatment information on lesions. We have successfully completed a program to realize the above-mentioned aims based on the following preexisting or initiated classifications or rules: 54 coronary artery circulations; a 17 myocardial segment model; the 3 areas delineated by 3 anatomical landmarks on the left heart surface; law of competitive myocardial blood supply for the 3 areas; and blood flow for parent vessels equals the summation of blood flow for daughter vessels. The utility of the 17 myocardial segment based coronary scoring system for prediction of outcomes will be investigated prospectively in the conduct of the trial: in acute myocardial infarction patients undergoing emergency percutaneous coronary intervention trial (AMI-EPCI trial). Once validated and standardized, the 17 myocardial segment based coronary scoring system will be available online.
	TO cite this article:XU Mingxing,HE Yongming. Derivation of a 17 myocardial segment angiographic scoring system and its validation[OL].[ 9 September 2017] http://en.paper.edu.cn/en_releasepaper/content/4741405


	7. Clinicopathological and prognostic significance of circulating tumor cells in patients with esophageal cancer : A meta-analysis
	Hou Jinxuan,Zou Kun,Xu Yu
	Clinical Medicine 09 September 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (882K B)

	Abstract:The aim of this meta-analysis was to assess the clinicopathological and prognostic significance of circulating tumor cells (CTCs) in patients with esophageal cancer. We searched PubMed, EMBASE, Science Citation Index Expanded, Cochrane library (from inception to October 2016) with the key words "esophageal cancer", "circulating tumor cells", "prognosis" and "peripheral blood". Hazard ratio, risk ratio, odds ratio and their 95% confidence intervals were set as effect measures. All analyses were performed by STATA 12.0. 17 studies were retrieved, CTCs positive was significant associated with poor progression-free survival (HR = 2.55; 95%CI: 2.12-3.06) and overall survival (HR = 2.46; 95%CI: 1.

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